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Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss
Joint Authors
Li, Xiaowei
Wang, Jian
Shi, Lijuan
Chang, Ying
Aiken, Steve
Liu, Lijie
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Recent studies on animal models have shown that noise exposure that does not lead to permanent threshold shift (PTS) can cause considerable damage around the synapses between inner hair cells (IHCs) and type-I afferent auditory nerve fibers (ANFs).
Disruption of these synapses not only disables the innervated ANFs but also results in the slow degeneration of spiral ganglion neurons if the synapses are not reestablished.
Such a loss of ANFs should result in signal coding deficits, which are exacerbated by the bias of the damage toward synapses connecting low-spontaneous-rate (SR) ANFs, which are known to be vital for signal coding in noisy background.
As there is no PTS, these functional deficits cannot be detected using routine audiological evaluations and may be unknown to subjects who have them.
Such functional deficits in hearing without changes in sensitivity are generally called “noise-induced hidden hearing loss (NIHHL).” Here, we provide a brief review to address several critical issues related to NIHHL: (1) the mechanism of noise induced synaptic damage, (2) reversibility of the synaptic damage, (3) the functional deficits as the nature of NIHHL in animal studies, (4) evidence of NIHHL in human subjects, and (5) peripheral and central contribution of NIHHL.
American Psychological Association (APA)
Shi, Lijuan& Chang, Ying& Li, Xiaowei& Aiken, Steve& Liu, Lijie& Wang, Jian. 2016. Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss. Neural Plasticity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113209
Modern Language Association (MLA)
Shi, Lijuan…[et al.]. Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss. Neural Plasticity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113209
American Medical Association (AMA)
Shi, Lijuan& Chang, Ying& Li, Xiaowei& Aiken, Steve& Liu, Lijie& Wang, Jian. Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113209
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113209