![](/images/graphics-bg.png)
Developmental Dynamics of Rett Syndrome
Joint Authors
Feldman, Danielle
Banerjee, Abhishek
Sur, Mriganka
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Rett Syndrome was long considered to be simply a disorder of postnatal development, with phenotypes that manifest only late in development and into adulthood.
A variety of recent evidence demonstrates that the phenotypes of Rett Syndrome are present at the earliest stages of brain development, including developmental stages that define neurogenesis, migration, and patterning in addition to stages of synaptic and circuit development and plasticity.
These phenotypes arise from the pleotropic effects of MeCP2, which is expressed very early in neuronal progenitors and continues to be expressed into adulthood.
The effects of MeCP2 are mediated by diverse signaling, transcriptional, and epigenetic mechanisms.
Attempts to reverse the effects of Rett Syndrome need to take into account the developmental dynamics and temporal impact of MeCP2 loss.
American Psychological Association (APA)
Feldman, Danielle& Banerjee, Abhishek& Sur, Mriganka. 2016. Developmental Dynamics of Rett Syndrome. Neural Plasticity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113211
Modern Language Association (MLA)
Feldman, Danielle…[et al.]. Developmental Dynamics of Rett Syndrome. Neural Plasticity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113211
American Medical Association (AMA)
Feldman, Danielle& Banerjee, Abhishek& Sur, Mriganka. Developmental Dynamics of Rett Syndrome. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113211
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113211