Large and Small Dendritic Spines Serve Different Interacting Functions in Hippocampal Synaptic Plasticity and Homeostasis
Joint Authors
Paulin, Joshua J. W.
Haslehurst, Peter
Fellows, Alexander D.
Liu, Wenfei
Jackson, Joshua D.
Joel, Zelah
Cummings, Damian M.
Edwards, Frances A.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The laying down of memory requires strong stimulation resulting in specific changes in synaptic strength and corresponding changes in size of dendritic spines.
Strong stimuli can also be pathological, causing a homeostatic response, depressing and shrinking the synapse to prevent damage from too much Ca2+ influx.
But do all types of dendritic spines serve both of these apparently opposite functions? Using confocal microscopy in organotypic slices from mice expressing green fluorescent protein in hippocampal neurones, the size of individual spines along sections of dendrite has been tracked in response to application of tetraethylammonium.
This strong stimulus would be expected to cause both a protective homeostatic response and long-term potentiation.
We report separation of these functions, with spines of different sizes reacting differently to the same strong stimulus.
The immediate shrinkage of large spines suggests a homeostatic protective response during the period of potential danger.
In CA1, long-lasting growth of small spines subsequently occurs consolidating long-term potentiation but only after the large spines return to their original size.
In contrast, small spines do not change in dentate gyrus where potentiation does not occur.
The separation in time of these changes allows clear functional differentiation of spines of different sizes.
American Psychological Association (APA)
Paulin, Joshua J. W.& Haslehurst, Peter& Fellows, Alexander D.& Liu, Wenfei& Jackson, Joshua D.& Joel, Zelah…[et al.]. 2015. Large and Small Dendritic Spines Serve Different Interacting Functions in Hippocampal Synaptic Plasticity and Homeostasis. Neural Plasticity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113213
Modern Language Association (MLA)
Paulin, Joshua J. W.…[et al.]. Large and Small Dendritic Spines Serve Different Interacting Functions in Hippocampal Synaptic Plasticity and Homeostasis. Neural Plasticity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113213
American Medical Association (AMA)
Paulin, Joshua J. W.& Haslehurst, Peter& Fellows, Alexander D.& Liu, Wenfei& Jackson, Joshua D.& Joel, Zelah…[et al.]. Large and Small Dendritic Spines Serve Different Interacting Functions in Hippocampal Synaptic Plasticity and Homeostasis. Neural Plasticity. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113213
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113213