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Chronic Stress and Glucocorticoids: From Neuronal Plasticity to Neurodegeneration
Joint Authors
Vyas, Sheela
Rodrigues, Ana João
Silva, Joana Margarida
Tronche, Francois
Almeida, Osborne F. X.
Sotiropoulos, Ioannis
Sousa, Nuno
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Stress and stress hormones, glucocorticoids (GCs), exert widespread actions in central nervous system, ranging from the regulation of gene transcription, cellular signaling, modulation of synaptic structure, and transmission and glial function to behavior.
Their actions are mediated by glucocorticoid and mineralocorticoid receptors which are nuclear receptors/transcription factors.
While GCs primarily act to maintain homeostasis by inducing physiological and behavioral adaptation, prolonged exposure to stress and elevated GC levels may result in neuro- and psychopathology.
There is now ample evidence for cause-effect relationships between prolonged stress, elevated GC levels, and cognitive and mood disorders while the evidence for a link between chronic stress/GC and neurodegenerative disorders such as Alzheimer’s (AD) and Parkinson’s (PD) diseases is growing.
This brief review considers some of the cellular mechanisms through which stress and GC may contribute to the pathogenesis of AD and PD.
American Psychological Association (APA)
Vyas, Sheela& Rodrigues, Ana João& Silva, Joana Margarida& Tronche, Francois& Almeida, Osborne F. X.& Sousa, Nuno…[et al.]. 2016. Chronic Stress and Glucocorticoids: From Neuronal Plasticity to Neurodegeneration. Neural Plasticity،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1113222
Modern Language Association (MLA)
Vyas, Sheela…[et al.]. Chronic Stress and Glucocorticoids: From Neuronal Plasticity to Neurodegeneration. Neural Plasticity No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1113222
American Medical Association (AMA)
Vyas, Sheela& Rodrigues, Ana João& Silva, Joana Margarida& Tronche, Francois& Almeida, Osborne F. X.& Sousa, Nuno…[et al.]. Chronic Stress and Glucocorticoids: From Neuronal Plasticity to Neurodegeneration. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1113222
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113222