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The Role of Stress Regulation on Neural Plasticity in Pain Chronification
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Pain, especially chronic pain, is one of the most common clinical symptoms and has been considered as a worldwide healthcare problem.
The transition from acute to chronic pain is accompanied by a chain of alterations in physiology, pathology, and psychology.
Increasing clinical studies and complementary animal models have elucidated effects of stress regulation on the pain chronification via investigating activations of the hypothalamic-pituitary-adrenal (HPA) axis and changes in some crucial brain regions, including the amygdala, prefrontal cortex, and hippocampus.
Although individuals suffer from acute pain benefit from such physiological alterations, chronic pain is commonly associated with maladaptive responses, like the HPA dysfunction and abnormal brain plasticity.
However, the causal relationship among pain chronification, stress regulation, and brain alterations is rarely discussed.
To call for more attention on this issue, we review recent findings obtained from clinical populations and animal models, propose an integrated stress model of pain chronification based on the existing models in perspectives of environmental influences and genetic predispositions, and discuss the significance of investigating the role of stress regulation on brain alteration in pain chronification for various clinical applications.
American Psychological Association (APA)
Li, Xiaoyun& Hu, Li. 2016. The Role of Stress Regulation on Neural Plasticity in Pain Chronification. Neural Plasticity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113223
Modern Language Association (MLA)
Li, Xiaoyun& Hu, Li. The Role of Stress Regulation on Neural Plasticity in Pain Chronification. Neural Plasticity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113223
American Medical Association (AMA)
Li, Xiaoyun& Hu, Li. The Role of Stress Regulation on Neural Plasticity in Pain Chronification. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113223
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113223