Age-Dependent Switch of the Role of Serotonergic 5-HT1A Receptors in Gating Long-Term Potentiation in Rat Visual Cortex In Vivo
Joint Authors
Dringenberg, Hans C.
Gagolewicz, Peter J.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The rodent primary visual cortex (V1) is densely innervated by serotonergic axons and previous in vitro work has shown that serotonin (5-HT) can modulate plasticity (e.g., long-term potentiation (LTP)) at V1 synapses.
However, little work has examined the effects of 5-HT on LTP under in vivo conditions.
We examined the role of 5-HT on LTP in V1 elicited by theta burst stimulation (TBS) of the lateral geniculate nucleus in urethane-anesthetized (adult and juvenile) rats.
Thalamic TBS consistently induced potentiation of field postsynaptic potentials (fPSPs) recorded in V1.
While 5-HT application (0.1–10 mM) itself did not alter LTP levels, the broad-acting 5-HT receptor antagonists methiothepin (1 mM) resulted in a clear facilitation of LTP in adult animals, an effect that was mimicked by the selective 5- H T 1 A receptor antagonist WAY 100635 (1 mM).
Interestingly, in juvenile rats, WAY 100635 application inhibited LTP, indicative of an age-dependent switch in the role of 5- H T 1 A receptors in gating V1 plasticity.
Analyses of spontaneous electrocorticographic (ECoG) activity in V1 indicated that the antagonist-induced LTP enhancement was not related to systematic changes in oscillatory activity in V1.
Together, these data suggest a facilitating role of 5- H T 1 A receptor activation on LTP in the juvenile V1, which switches to a tonic, inhibitory influence in adulthood.
American Psychological Association (APA)
Gagolewicz, Peter J.& Dringenberg, Hans C.. 2016. Age-Dependent Switch of the Role of Serotonergic 5-HT1A Receptors in Gating Long-Term Potentiation in Rat Visual Cortex In Vivo. Neural Plasticity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113225
Modern Language Association (MLA)
Gagolewicz, Peter J.& Dringenberg, Hans C.. Age-Dependent Switch of the Role of Serotonergic 5-HT1A Receptors in Gating Long-Term Potentiation in Rat Visual Cortex In Vivo. Neural Plasticity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113225
American Medical Association (AMA)
Gagolewicz, Peter J.& Dringenberg, Hans C.. Age-Dependent Switch of the Role of Serotonergic 5-HT1A Receptors in Gating Long-Term Potentiation in Rat Visual Cortex In Vivo. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113225
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113225