Mismatch Negativity and P50 Sensory Gating in Abstinent Former Cannabis Users
Joint Authors
Broyd, Samantha J.
Greenwood, Lisa-marie
van Hell, Hendrika H.
Croft, Rodney J.
Coyle, Hannah
Lee-Bates, Ben
Todd, Juanita
Johnstone, Stuart J.
Michie, Patricia T.
Solowij, Nadia
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Prolonged heavy exposure to cannabis is associated with impaired cognition and brain functional and structural alterations.
We recently reported attenuated mismatch negativity (MMN) and altered P50 sensory gating in chronic cannabis users.
This study investigated the extent of brain functional recovery (indexed by MMN and P50) in chronic users after cessation of use.
Eighteen ex-users (median 13.5 years prior regular use; median 3.5 years abstinence) and 18 nonusers completed (1) a multifeature oddball task with duration, frequency, and intensity deviants and (2) a P50 paired-click paradigm.
Trend level smaller duration MMN amplitude and larger P50 ratios (indicative of poorer sensory gating) were observed in ex-users compared to controls.
Poorer P50 gating correlated with prior duration of cannabis use.
Duration of abstinence was positively correlated with duration MMN amplitude, even after controlling for age and duration of cannabis use.
Impaired sensory gating and attenuated MMN amplitude tended to persist in ex-users after prolonged cessation of use, suggesting a lack of full recovery.
An association with prolonged duration of prior cannabis use may indicate persistent cannabis-related alterations to P50 sensory gating.
Greater reductions in MMN amplitude with increasing abstinence (positive correlation) may be related to either self-medication or an accelerated aging process.
American Psychological Association (APA)
Broyd, Samantha J.& Greenwood, Lisa-marie& van Hell, Hendrika H.& Croft, Rodney J.& Coyle, Hannah& Lee-Bates, Ben…[et al.]. 2016. Mismatch Negativity and P50 Sensory Gating in Abstinent Former Cannabis Users. Neural Plasticity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113232
Modern Language Association (MLA)
Broyd, Samantha J.…[et al.]. Mismatch Negativity and P50 Sensory Gating in Abstinent Former Cannabis Users. Neural Plasticity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113232
American Medical Association (AMA)
Broyd, Samantha J.& Greenwood, Lisa-marie& van Hell, Hendrika H.& Croft, Rodney J.& Coyle, Hannah& Lee-Bates, Ben…[et al.]. Mismatch Negativity and P50 Sensory Gating in Abstinent Former Cannabis Users. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113232
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113232