Loss of Myh14 Increases Susceptibility to Noise-Induced Hearing Loss in CBACaJ Mice
Joint Authors
Fu, Xiaolong
Zhang, Linqing
Jin, Yecheng
Sun, Xiaoyang
Zhang, Aizhen
Wen, Zongzhuang
Zhou, Yichen
Xia, Ming
Gao, Jiangang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-22
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
MYH14 is a member of the myosin family, which has been implicated in many motile processes such as ion-channel gating, organelle translocation, and the cytoskeleton rearrangement.
Mutations in MYH14 lead to a DFNA4-type hearing impairment.
Further evidence also shows that MYH14 is a candidate noise-induced hearing loss (NIHL) susceptible gene.
However, the specific roles of MYH14 in auditory function and NIHL are not fully understood.
In the present study, we used CRISPR/Cas9 technology to establish a Myh14 knockout mice line in CBA/CaJ background (now referred to as Myh14−/− mice) and clarify the role of MYH14 in the cochlea and NIHL.
We found that Myh14−/− mice did not exhibit significant hearing loss until five months of age.
In addition, Myh14−/− mice were more vulnerable to high intensity noise compared to control mice.
More significant outer hair cell loss was observed in Myh14−/− mice than in wild type controls after acoustic trauma.
Our findings suggest that Myh14 may play a beneficial role in the protection of the cochlea after acoustic overstimulation in CBA/CaJ mice.
American Psychological Association (APA)
Fu, Xiaolong& Zhang, Linqing& Jin, Yecheng& Sun, Xiaoyang& Zhang, Aizhen& Wen, Zongzhuang…[et al.]. 2016. Loss of Myh14 Increases Susceptibility to Noise-Induced Hearing Loss in CBACaJ Mice. Neural Plasticity،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113236
Modern Language Association (MLA)
Fu, Xiaolong…[et al.]. Loss of Myh14 Increases Susceptibility to Noise-Induced Hearing Loss in CBACaJ Mice. Neural Plasticity No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1113236
American Medical Association (AMA)
Fu, Xiaolong& Zhang, Linqing& Jin, Yecheng& Sun, Xiaoyang& Zhang, Aizhen& Wen, Zongzhuang…[et al.]. Loss of Myh14 Increases Susceptibility to Noise-Induced Hearing Loss in CBACaJ Mice. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113236
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113236