Phosphorylation of CRMP2 by Cdk5 Regulates Dendritic Spine Development of Cortical Neuron in the Mouse Hippocampus
Joint Authors
Jin, Xiaohua
Sasamoto, Kodai
Nagai, Jun
Yamazaki, Yuki
Saito, Kenta
Goshima, Yoshio
Inoue, Takafumi
Ohshima, Toshio
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Proper density and morphology of dendritic spines are important for higher brain functions such as learning and memory.
However, our knowledge about molecular mechanisms that regulate the development and maintenance of dendritic spines is limited.
We recently reported that cyclin-dependent kinase 5 (Cdk5) is required for the development and maintenance of dendritic spines of cortical neurons in the mouse brain.
Previous in vitro studies have suggested the involvement of Cdk5 substrates in the formation of dendritic spines; however, their role in spine development has not been tested in vivo.
Here, we demonstrate that Cdk5 phosphorylates collapsin response mediator protein 2 (CRMP2) in the dendritic spines of cultured hippocampal neurons and in vivo in the mouse brain.
When we eliminated CRMP2 phosphorylation in CRMP2KI/KI mice, the densities of dendritic spines significantly decreased in hippocampal CA1 pyramidal neurons in the mouse brain.
These results indicate that phosphorylation of CRMP2 by Cdk5 is important for dendritic spine development in cortical neurons in the mouse hippocampus.
American Psychological Association (APA)
Jin, Xiaohua& Sasamoto, Kodai& Nagai, Jun& Yamazaki, Yuki& Saito, Kenta& Goshima, Yoshio…[et al.]. 2015. Phosphorylation of CRMP2 by Cdk5 Regulates Dendritic Spine Development of Cortical Neuron in the Mouse Hippocampus. Neural Plasticity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113241
Modern Language Association (MLA)
Jin, Xiaohua…[et al.]. Phosphorylation of CRMP2 by Cdk5 Regulates Dendritic Spine Development of Cortical Neuron in the Mouse Hippocampus. Neural Plasticity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1113241
American Medical Association (AMA)
Jin, Xiaohua& Sasamoto, Kodai& Nagai, Jun& Yamazaki, Yuki& Saito, Kenta& Goshima, Yoshio…[et al.]. Phosphorylation of CRMP2 by Cdk5 Regulates Dendritic Spine Development of Cortical Neuron in the Mouse Hippocampus. Neural Plasticity. 2015. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113241