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A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice
Joint Authors
Heerschap, Arend
Wiesmann, Maximilian
Zerbi, Valerio
Jansen, Diane
Haast, Roy
Broersen, Laus M.
Kiliaan, Amanda J.
Lütjohann, Dieter
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-10
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
APOE ε4 (apoE4) polymorphism is the main genetic determinant of sporadic Alzheimer’s disease (AD).
A dietary approach (Fortasyn) including docosahexaenoic acid, eicosapentaenoic acid, uridine, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium has been proposed for dietary management of AD.
We hypothesize that the diet could inhibit AD-like pathologies in apoE4 mice, specifically cerebrovascular and connectivity impairment.
Moreover, we evaluated the diet effect on cerebral blood flow (CBF), functional connectivity (FC), gray/white matter integrity, and postsynaptic density in aging apoE4 mice.
At 10–12 months, apoE4 mice did not display prominent pathological differences compared to wild-type (WT) mice.
However, 16–18-month-old apoE4 mice revealed reduced CBF and accelerated synaptic loss.
The diet increased cortical CBF and amount of synapses and improved white matter integrity and FC in both aging apoE4 and WT mice.
We demonstrated that protective mechanisms on vascular and synapse health are enhanced by Fortasyn, independent of apoE genotype.
We further showed the efficacy of a multimodal translational approach, including advanced MR neuroimaging, to study dietary intervention on brain structure and function in aging.
American Psychological Association (APA)
Wiesmann, Maximilian& Zerbi, Valerio& Jansen, Diane& Haast, Roy & Lütjohann, Dieter& Broersen, Laus M.…[et al.]. 2016. A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice. Neural Plasticity،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1113247
Modern Language Association (MLA)
Wiesmann, Maximilian…[et al.]. A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice. Neural Plasticity No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1113247
American Medical Association (AMA)
Wiesmann, Maximilian& Zerbi, Valerio& Jansen, Diane& Haast, Roy & Lütjohann, Dieter& Broersen, Laus M.…[et al.]. A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1113247
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113247