Influence of Genetic Variants of the N-Methyl-D-Aspartate Receptor on Emotion and Social Behavior in Adolescents
Joint Authors
Lee, Li-Ching
Yeh, Ting-Kuang
Cho, Ying-Chun
Chang, Chun-Yen
Lin, Pei-Jung
Yeh, Ting-Chi
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Considerable evidence has suggested that the epigenetic regulation of N-methyl-D-aspartate (NMDA) glutamate receptors plays a crucial role in neuropsychiatric disorders.
Previous exploratory studies have been primarily based on evidence from patients and have rarely sampled the general population.
This exploratory study examined the relationship of single-nucleotide polymorphism (SNP) variations in the genes encoding the NMDA receptor (i.e., GRIN1, GRIN2A, GRIN2B, GRIN2C, and GRIN2D) with emotion and social behavior in adolescents.
For this study, 832 tenth-grade Taiwanese volunteers were recruited, and their scores from the Beck Youth Inventories were used to evaluate their emotional and social impairments.
Based on these scores, GRIN1 (rs4880213) was significantly associated with depression and disruptive behavior.
In addition, GRIN2B (rs7301328) was significantly associated with disruptive behavior.
Because emotional and social impairment greatly influence learning ability, the findings of this study provide important information for clinical treatment and the development of promising prevention and treatment strategies, especially in the area of psychological adjustment.
American Psychological Association (APA)
Lee, Li-Ching& Cho, Ying-Chun& Lin, Pei-Jung& Yeh, Ting-Chi& Chang, Chun-Yen& Yeh, Ting-Kuang. 2015. Influence of Genetic Variants of the N-Methyl-D-Aspartate Receptor on Emotion and Social Behavior in Adolescents. Neural Plasticity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113248
Modern Language Association (MLA)
Lee, Li-Ching…[et al.]. Influence of Genetic Variants of the N-Methyl-D-Aspartate Receptor on Emotion and Social Behavior in Adolescents. Neural Plasticity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1113248
American Medical Association (AMA)
Lee, Li-Ching& Cho, Ying-Chun& Lin, Pei-Jung& Yeh, Ting-Chi& Chang, Chun-Yen& Yeh, Ting-Kuang. Influence of Genetic Variants of the N-Methyl-D-Aspartate Receptor on Emotion and Social Behavior in Adolescents. Neural Plasticity. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113248