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Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB
Joint Authors
Engelmann, Christian
Haenold, Ronny
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Activation of nuclear factor kappa B (NF-κB) transcription factors is required for the induction of synaptic plasticity and memory formation.
All components of this signaling pathway are localized at synapses, and transcriptionally active NF-κB dimers move to the nucleus to translate synaptic signals into altered gene expression.
Neuron-specific inhibition results in altered connectivity of excitatory and inhibitory synapses and functionally in selective learning deficits.
Recent research on transgenic mice with impaired or hyperactivated NF-κB gave important insights into plasticity-related target gene expression that is regulated by NF-κB.
In this minireview, we update the available data on the role of this transcription factor for learning and memory formation and comment on cross-sectional activation of NF-κB in the aged and diseased brain that may directly or indirectly affect κB-dependent transcription of synaptic genes.
American Psychological Association (APA)
Engelmann, Christian& Haenold, Ronny. 2016. Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB. Neural Plasticity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113253
Modern Language Association (MLA)
Engelmann, Christian& Haenold, Ronny. Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB. Neural Plasticity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1113253
American Medical Association (AMA)
Engelmann, Christian& Haenold, Ronny. Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113253