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Sensory Cortical Plasticity Participates in the Epigenetic Regulation of Robust Memory Formation
Joint Authors
Phan, Mimi L.
Bieszczad, Kasia M.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Neuroplasticity remodels sensory cortex across the lifespan.
A function of adult sensory cortical plasticity may be capturing available information during perception for memory formation.
The degree of experience-dependent remodeling in sensory cortex appears to determine memory strength and specificity for important sensory signals.
A key open question is how plasticity is engaged to induce different degrees of sensory cortical remodeling.
Neural plasticity for long-term memory requires the expression of genes underlying stable changes in neuronal function, structure, connectivity, and, ultimately, behavior.
Lasting changes in transcriptional activity may depend on epigenetic mechanisms; some of the best studied in behavioral neuroscience are DNA methylation and histone acetylation and deacetylation, which, respectively, promote and repress gene expression.
One purpose of this review is to propose epigenetic regulation of sensory cortical remodeling as a mechanism enabling the transformation of significant information from experiences into content-rich memories of those experiences.
Recent evidence suggests how epigenetic mechanisms regulate highly specific reorganization of sensory cortical representations that establish a widespread network for memory.
Thus, epigenetic mechanisms could initiate events to establish exceptionally persistent and robust memories at a systems-wide level by engaging sensory cortical plasticity for gating what and how much information becomes encoded.
American Psychological Association (APA)
Phan, Mimi L.& Bieszczad, Kasia M.. 2016. Sensory Cortical Plasticity Participates in the Epigenetic Regulation of Robust Memory Formation. Neural Plasticity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113261
Modern Language Association (MLA)
Phan, Mimi L.& Bieszczad, Kasia M.. Sensory Cortical Plasticity Participates in the Epigenetic Regulation of Robust Memory Formation. Neural Plasticity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113261
American Medical Association (AMA)
Phan, Mimi L.& Bieszczad, Kasia M.. Sensory Cortical Plasticity Participates in the Epigenetic Regulation of Robust Memory Formation. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113261
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113261