Caught in the Net: Perineuronal Nets and Addiction
Joint Authors
Slaker, Megan
Blacktop, Jordan M.
Sorg, Barbara A.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Exposure to drugs of abuse induces plasticity in the brain and creates persistent drug-related memories.
These changes in plasticity and persistent drug memories are believed to produce aberrant motivation and reinforcement contributing to addiction.
Most studies have explored the effect drugs of abuse have on pre- and postsynaptic cells and astrocytes; however, more recently, attention has shifted to explore the effect these drugs have on the extracellular matrix (ECM).
Within the ECM are unique structures arranged in a net-like manner, surrounding a subset of neurons called perineuronal nets (PNNs).
This review focuses on drug-induced changes in PNNs, the molecules that regulate PNNs, and the expression of PNNs within brain circuitry mediating motivation, reward, and reinforcement as it pertains to addiction.
American Psychological Association (APA)
Slaker, Megan& Blacktop, Jordan M.& Sorg, Barbara A.. 2016. Caught in the Net: Perineuronal Nets and Addiction. Neural Plasticity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113282
Modern Language Association (MLA)
Slaker, Megan…[et al.]. Caught in the Net: Perineuronal Nets and Addiction. Neural Plasticity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1113282
American Medical Association (AMA)
Slaker, Megan& Blacktop, Jordan M.& Sorg, Barbara A.. Caught in the Net: Perineuronal Nets and Addiction. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113282
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113282