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Impaired Functional Connectivity in the Prefrontal Cortex: A Mechanism for Chronic Stress-Induced Neuropsychiatric Disorders
Joint Authors
Negrón-Oyarzo, Ignacio
Aboitiz, Francisco
Fuentealba, Pablo
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-19
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Chronic stress-related psychiatric diseases, such as major depression, posttraumatic stress disorder, and schizophrenia, are characterized by a maladaptive organization of behavioral responses that strongly affect the well-being of patients.
Current evidence suggests that a functional impairment of the prefrontal cortex (PFC) is implicated in the pathophysiology of these diseases.
Therefore, chronic stress may impair PFC functions required for the adaptive orchestration of behavioral responses.
In the present review, we integrate evidence obtained from cognitive neuroscience with neurophysiological research with animal models, to put forward a hypothesis that addresses stress-induced behavioral dysfunctions observed in stress-related neuropsychiatric disorders.
We propose that chronic stress impairs mechanisms involved in neuronal functional connectivity in the PFC that are required for the formation of adaptive representations for the execution of adaptive behavioral responses.
These considerations could be particularly relevant for understanding the pathophysiology of chronic stress-related neuropsychiatric disorders.
American Psychological Association (APA)
Negrón-Oyarzo, Ignacio& Aboitiz, Francisco& Fuentealba, Pablo. 2016. Impaired Functional Connectivity in the Prefrontal Cortex: A Mechanism for Chronic Stress-Induced Neuropsychiatric Disorders. Neural Plasticity،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113285
Modern Language Association (MLA)
Negrón-Oyarzo, Ignacio…[et al.]. Impaired Functional Connectivity in the Prefrontal Cortex: A Mechanism for Chronic Stress-Induced Neuropsychiatric Disorders. Neural Plasticity No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1113285
American Medical Association (AMA)
Negrón-Oyarzo, Ignacio& Aboitiz, Francisco& Fuentealba, Pablo. Impaired Functional Connectivity in the Prefrontal Cortex: A Mechanism for Chronic Stress-Induced Neuropsychiatric Disorders. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113285
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113285