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Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study
Joint Authors
De Pittà, Maurizio
Brunel, Nicolas
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-30, 30 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-18
Country of Publication
Egypt
No. of Pages
30
Main Subjects
Abstract EN
Glutamatergic gliotransmission, that is, the release of glutamate from perisynaptic astrocyte processes in an activity-dependent manner, has emerged as a potentially crucial signaling pathway for regulation of synaptic plasticity, yet its modes of expression and function in vivo remain unclear.
Here, we focus on two experimentally well-identified gliotransmitter pathways, (i) modulations of synaptic release and (ii) postsynaptic slow inward currents mediated by glutamate released from astrocytes, and investigate their possible functional relevance on synaptic plasticity in a biophysical model of an astrocyte-regulated synapse.
Our model predicts that both pathways could profoundly affect both short- and long-term plasticity.
In particular, activity-dependent glutamate release from astrocytes could dramatically change spike-timing-dependent plasticity, turning potentiation into depression (and vice versa) for the same induction protocol.
American Psychological Association (APA)
De Pittà, Maurizio& Brunel, Nicolas. 2016. Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study. Neural Plasticity،Vol. 2016, no. 2016, pp.1-30.
https://search.emarefa.net/detail/BIM-1113286
Modern Language Association (MLA)
De Pittà, Maurizio& Brunel, Nicolas. Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study. Neural Plasticity No. 2016 (2016), pp.1-30.
https://search.emarefa.net/detail/BIM-1113286
American Medical Association (AMA)
De Pittà, Maurizio& Brunel, Nicolas. Modulation of Synaptic Plasticity by Glutamatergic Gliotransmission: A Modeling Study. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-30.
https://search.emarefa.net/detail/BIM-1113286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113286