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Otx2-PNN Interaction to Regulate Cortical Plasticity
Joint Authors
Prochiantz, Alain
Bernard, Clémence
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The ability of the environment to shape cortical function is at its highest during critical periods of postnatal development.
In the visual cortex, critical period onset is triggered by the maturation of parvalbumin inhibitory interneurons, which gradually become surrounded by a specialized glycosaminoglycan-rich extracellular matrix: the perineuronal nets.
Among the identified factors regulating cortical plasticity in the visual cortex, extracortical homeoprotein Otx2 is transferred specifically into parvalbumin interneurons and this transfer regulates both the onset and the closure of the critical period of plasticity for binocular vision.
Here, we review the interaction between the complex sugars of the perineuronal nets and homeoprotein Otx2 and how this interaction regulates cortical plasticity during critical period and in adulthood.
American Psychological Association (APA)
Bernard, Clémence& Prochiantz, Alain. 2016. Otx2-PNN Interaction to Regulate Cortical Plasticity. Neural Plasticity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113289
Modern Language Association (MLA)
Bernard, Clémence& Prochiantz, Alain. Otx2-PNN Interaction to Regulate Cortical Plasticity. Neural Plasticity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1113289
American Medical Association (AMA)
Bernard, Clémence& Prochiantz, Alain. Otx2-PNN Interaction to Regulate Cortical Plasticity. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113289
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113289