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Deep Brain Stimulation for Obesity: From a Theoretical Framework to Practical Application
Joint Authors
Nangunoori, Raj K.
Tomycz, Nestor D.
Oh, Michael Y.
Whiting, Donald M.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Obesity remains a pervasive global health problem.
While there are a number of nonsurgical and surgical options for treatment, the incidence of obesity continues to increase at an alarming rate.
The inability to curtail the growing rise of the obesity epidemic may be related to a combination of increased food availability and palatability.
Research into feeding behavior has yielded a number of insights into the homeostatic and reward mechanisms that govern feeding.
However, there remains a gap between laboratory investigations of feeding physiology in animals and translation into meaningful treatment options for humans.
In addition, laboratory investigation may not be able to recapitulate all aspects of human food consumption.
In a landmark pilot study of deep brain stimulation (DBS) of the lateral hypothalamic area for obesity, we found that there was an increase in resting metabolic rate as well as a decreased urge to eat.
In this review, the authors will review some of the work relating to feeding physiology and research surrounding two nodes involved in feeding homeostasis, nucleus accumbens (NAc) and hypothalamus, and use this to provide a framework for future investigations of DBS as a viable therapeutic modality for obesity.
American Psychological Association (APA)
Nangunoori, Raj K.& Tomycz, Nestor D.& Oh, Michael Y.& Whiting, Donald M.. 2015. Deep Brain Stimulation for Obesity: From a Theoretical Framework to Practical Application. Neural Plasticity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113293
Modern Language Association (MLA)
Nangunoori, Raj K.…[et al.]. Deep Brain Stimulation for Obesity: From a Theoretical Framework to Practical Application. Neural Plasticity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1113293
American Medical Association (AMA)
Nangunoori, Raj K.& Tomycz, Nestor D.& Oh, Michael Y.& Whiting, Donald M.. Deep Brain Stimulation for Obesity: From a Theoretical Framework to Practical Application. Neural Plasticity. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113293