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Activation of Sphingosine 1-Phosphate Receptor 1 Enhances Hippocampus Neurogenesis in a Rat Model of Traumatic Brain Injury: An Involvement of MEKErk Signaling Pathway
Joint Authors
Ye, Yuqin
Xu, Hongyu
Su, Xinhong
He, Xiaosheng
Zhao, Zhenyu
Zhang, Xin
Yang, Yongxiang
Yu, Xinguang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-29
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Among sphingosine 1-phosphate receptors (S1PRs) family, S1PR1 has been shown to be the most highly expressed subtype in neural stem cells (NSCs) and plays a crucial role in the migratory property of NSCs.
Recent studies suggested that S1PR1 was expressed abundantly in the hippocampus, a specific neurogenic region in rodent brain for endogenous neurogenesis throughout life.
However, the potential association between S1PR1 and neurogenesis in hippocampus following traumatic brain injury (TBI) remains unknown.
In this study, the changes of hippocampal S1PR1 expression after TBI and their effects on neurogenesis and neurocognitive function were investigated, focusing on particularly the extracellular signal-regulated kinase (Erk) signaling pathway which had been found to regulate multiple properties of NSCs.
The results showed that a marked upregulation of S1PR1 occurred with a peak at 7 days after trauma, revealing an enhancement of proliferation and neuronal differentiation of NSCs in hippocampus due to S1PR1 activation.
More importantly, it was suggested that mitogen-activated protein kinase-Erk kinase (MEK)/Erk cascade was required for S1PR1-meidated neurogenesis and neurocognitive recovery following TBI.
This study lays a preliminary foundation for future research on promoting hippocampal neurogenesis and improving TBI outcome.
American Psychological Association (APA)
Ye, Yuqin& Zhao, Zhenyu& Xu, Hongyu& Zhang, Xin& Su, Xinhong& Yang, Yongxiang…[et al.]. 2016. Activation of Sphingosine 1-Phosphate Receptor 1 Enhances Hippocampus Neurogenesis in a Rat Model of Traumatic Brain Injury: An Involvement of MEKErk Signaling Pathway. Neural Plasticity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113305
Modern Language Association (MLA)
Ye, Yuqin…[et al.]. Activation of Sphingosine 1-Phosphate Receptor 1 Enhances Hippocampus Neurogenesis in a Rat Model of Traumatic Brain Injury: An Involvement of MEKErk Signaling Pathway. Neural Plasticity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1113305
American Medical Association (AMA)
Ye, Yuqin& Zhao, Zhenyu& Xu, Hongyu& Zhang, Xin& Su, Xinhong& Yang, Yongxiang…[et al.]. Activation of Sphingosine 1-Phosphate Receptor 1 Enhances Hippocampus Neurogenesis in a Rat Model of Traumatic Brain Injury: An Involvement of MEKErk Signaling Pathway. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113305
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113305