Endogenous and Synthetic Cannabinoids as Therapeutics in Retinal Disease
Joint Authors
Kokona, Despina
Georgiou, Panagiota-Christina
Kounenidakis, Mihalis
Kiagiadaki, Foteini
Thermos, Kyriaki
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The functional significance of cannabinoids in ocular physiology and disease has been reported some decades ago.
In the early 1970s, subjects who smoked Cannabis sativa developed lower intraocular pressure (IOP).
This led to the isolation of phytocannabinoids from this plant and the study of their therapeutic effects in glaucoma.
The main treatment of this disease to date involves the administration of drugs mediating either the decrease of aqueous humour synthesis or the increase of its outflow and thus reduces IOP.
However, the reduction of IOP is not sufficient to prevent visual field loss.
Retinal diseases, such as glaucoma and diabetic retinopathy, have been defined as neurodegenerative diseases and characterized by ischemia-induced excitotoxicity and loss of retinal neurons.
Therefore, new therapeutic strategies must be applied in order to target retinal cell death, reduction of visual acuity, and blindness.
The aim of the present review is to address the neuroprotective and therapeutic potential of cannabinoids in retinal disease.
American Psychological Association (APA)
Kokona, Despina& Georgiou, Panagiota-Christina& Kounenidakis, Mihalis& Kiagiadaki, Foteini& Thermos, Kyriaki. 2016. Endogenous and Synthetic Cannabinoids as Therapeutics in Retinal Disease. Neural Plasticity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113333
Modern Language Association (MLA)
Kokona, Despina…[et al.]. Endogenous and Synthetic Cannabinoids as Therapeutics in Retinal Disease. Neural Plasticity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113333
American Medical Association (AMA)
Kokona, Despina& Georgiou, Panagiota-Christina& Kounenidakis, Mihalis& Kiagiadaki, Foteini& Thermos, Kyriaki. Endogenous and Synthetic Cannabinoids as Therapeutics in Retinal Disease. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113333
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113333