Plasma Membrane Targeting of Protocadherin 15 Is Regulated by the Golgi-Associated Chaperone Protein PIST
Joint Authors
Xiong, Wei
Nie, Hongyun
Liu, Yueyue
Yin, Xiaolei
Cao, Huiren
Wang, Yanfei
Lin, Yushuang
Xu, Zhigang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Protocadherin 15 (PCDH15) is a core component of hair cell tip-links and crucial for proper function of inner ear hair cells.
Mutations of PCDH15 gene cause syndromic and nonsyndromic hearing loss.
At present, the regulatory mechanisms responsible for the intracellular transportation of PCDH15 largely remain unknown.
Here we show that PIST, a Golgi-associated, PDZ domain-containing protein, interacts with PCDH15.
The interaction is mediated by the PDZ domain of PIST and the C-terminal PDZ domain-binding interface (PBI) of PCDH15.
Through this interaction, PIST retains PCDH15 in the trans-Golgi network (TGN) and reduces the membrane expression of PCDH15.
We have previously showed that PIST regulates the membrane expression of another tip-link component, cadherin 23 (CDH23).
Taken together, our finding suggests that PIST regulates the intracellular trafficking and membrane targeting of the tip-link proteins CDH23 and PCDH15.
American Psychological Association (APA)
Nie, Hongyun& Liu, Yueyue& Yin, Xiaolei& Cao, Huiren& Wang, Yanfei& Xiong, Wei…[et al.]. 2016. Plasma Membrane Targeting of Protocadherin 15 Is Regulated by the Golgi-Associated Chaperone Protein PIST. Neural Plasticity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113346
Modern Language Association (MLA)
Nie, Hongyun…[et al.]. Plasma Membrane Targeting of Protocadherin 15 Is Regulated by the Golgi-Associated Chaperone Protein PIST. Neural Plasticity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113346
American Medical Association (AMA)
Nie, Hongyun& Liu, Yueyue& Yin, Xiaolei& Cao, Huiren& Wang, Yanfei& Xiong, Wei…[et al.]. Plasma Membrane Targeting of Protocadherin 15 Is Regulated by the Golgi-Associated Chaperone Protein PIST. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113346
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113346