Cortical Reorganization following Injury Early in Life
Joint Authors
Weinstein, Maya
Myers, Vicki
Green, Dido
Schertz, Mitchell
Shiran, Shelly I.
Artzi, Moran
Ben Bashat, Dafna
Tarrasch, Ricardo
Fattal-Valevski, Aviva
Miller, Elka
Gordon, Andrew M.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The brain has a remarkable capacity for reorganization following injury, especially during the first years of life.
Knowledge of structural reorganization and its consequences following perinatal injury is sparse.
Here we studied changes in brain tissue volume, morphology, perfusion, and integrity in children with hemiplegia compared to typically developing children, using MRI.
Children with hemiplegia demonstrated reduced total cerebral volume, with increased cerebrospinal fluid (CSF) and reduced total white matter volumes, with no differences in total gray matter volume, compared to typically developing children.
An increase in cortical thickness at the hemisphere contralateral to the lesion (CLH) was detected in motor and language areas, which may reflect compensation for the gray matter loss in the lesion area or retention of ipsilateral pathways.
In addition, reduced cortical thickness, perfusion, and surface area were detected in limbic areas.
Increased CSF volume and precentral cortical thickness and reduced white matter volume were correlated with worse motor performance.
Brain reorganization of the gray matter within the CLH, while not necessarily indicating better outcome, is suggested as a response to neuronal deficits following injury early in life.
American Psychological Association (APA)
Artzi, Moran& Shiran, Shelly I.& Weinstein, Maya& Myers, Vicki& Tarrasch, Ricardo& Schertz, Mitchell…[et al.]. 2016. Cortical Reorganization following Injury Early in Life. Neural Plasticity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113352
Modern Language Association (MLA)
Artzi, Moran…[et al.]. Cortical Reorganization following Injury Early in Life. Neural Plasticity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113352
American Medical Association (AMA)
Artzi, Moran& Shiran, Shelly I.& Weinstein, Maya& Myers, Vicki& Tarrasch, Ricardo& Schertz, Mitchell…[et al.]. Cortical Reorganization following Injury Early in Life. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113352
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113352