The Endocannabinoid System as a Therapeutic Target in Glaucoma
Joint Authors
Kelly, M. E. M.
Cairns, Elizabeth A.
Baldridge, William H.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Glaucoma is an irreversible blinding eye disease which produces progressive retinal ganglion cell (RGC) loss.
Intraocular pressure (IOP) is currently the only modifiable risk factor, and lowering IOP results in reduced risk of progression of the disorder.
The endocannabinoid system (ECS) has attracted considerable attention as a potential target for the treatment of glaucoma, largely due to the observed IOP lowering effects seen after administration of exogenous cannabinoids.
However, recent evidence has suggested that modulation of the ECS may also be neuroprotective.
This paper will review the use of cannabinoids in glaucoma, presenting pertinent information regarding the pathophysiology of glaucoma and how alterations in cannabinoid signalling may contribute to glaucoma pathology.
Additionally, the mechanisms and potential for the use of cannabinoids and other novel agents that target the endocannabinoid system in the treatment of glaucoma will be discussed.
American Psychological Association (APA)
Cairns, Elizabeth A.& Baldridge, William H.& Kelly, M. E. M.. 2016. The Endocannabinoid System as a Therapeutic Target in Glaucoma. Neural Plasticity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113383
Modern Language Association (MLA)
Cairns, Elizabeth A.…[et al.]. The Endocannabinoid System as a Therapeutic Target in Glaucoma. Neural Plasticity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113383
American Medical Association (AMA)
Cairns, Elizabeth A.& Baldridge, William H.& Kelly, M. E. M.. The Endocannabinoid System as a Therapeutic Target in Glaucoma. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113383