Progress of Research on Diffuse Axonal Injury after Traumatic Brain Injury
Joint Authors
Ma, Junwei
Zhang, Kai
Wang, Zhimin
Hang, Chunhua
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The current work reviews the concept, pathological mechanism, and process of diagnosing of DAI.
The pathological mechanism underlying DAI is complicated, including axonal breakage caused by axonal retraction balls, discontinued protein transport along the axonal axis, calcium influx, and calpain-mediated hydrolysis of structural protein, degradation of axonal cytoskeleton network, the changes of transport proteins such as amyloid precursor protein, and changes of glia cells.
Based on the above pathological mechanism, the diagnosis of DAI is usually made using methods such as CT, traditional and new MRI, biochemical markers, and neuropsychological assessment.
This review provides a basis in literature for further investigation and discusses the pathological mechanism.
It may also facilitate improvement of the accuracy of diagnosis for DAI, which may come to play a critical role in breaking through the bottleneck of the clinical treatment of DAI and improving the survival and quality of life of patients through clear understanding of pathological mechanisms and accurate diagnosis.
American Psychological Association (APA)
Ma, Junwei& Zhang, Kai& Wang, Zhimin& Hang, Chunhua. 2016. Progress of Research on Diffuse Axonal Injury after Traumatic Brain Injury. Neural Plasticity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113391
Modern Language Association (MLA)
Ma, Junwei…[et al.]. Progress of Research on Diffuse Axonal Injury after Traumatic Brain Injury. Neural Plasticity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1113391
American Medical Association (AMA)
Ma, Junwei& Zhang, Kai& Wang, Zhimin& Hang, Chunhua. Progress of Research on Diffuse Axonal Injury after Traumatic Brain Injury. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1113391
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113391