![](/images/graphics-bg.png)
Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice
Joint Authors
Prange-Kiel, Janine
Dudzinski, Danuta A.
Pröls, Felicitas
Glatzel, Markus
Matschke, Jakob
Rune, Gabriele M.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Numerous studies show that 17β-estradiol (E2) protects against Alzheimer’s disease (AD) induced neurodegeneration.
The E2-synthesizing enzyme aromatase is expressed in healthy hippocampi, but although the hippocampus is severely affected in AD, little is known about the expression of hippocampal aromatase in AD.
To better understand the role of hippocampal aromatase in AD, we studied its expression in postmortem material from patients with AD and in a mouse model for AD (5xFAD mice).
In human hippocampi, aromatase-immunoreactivity was observed in the vast majority of principal neurons and signal quantification revealed higher expression of aromatase protein in AD patients compared to age- and sex-matched controls.
The tissue-specific first exons of aromatase I.f, PII, I.3, and I.6 were detected in hippocampi of controls and AD patients by RT-PCR.
In contrast, 3-month-old, female 5xFAD mice showed lower expression of aromatase mRNA and protein (measured by qRT-PCR and semiquantitative immunohistochemistry) than WT controls; no such differences were observed in male mice.
Our findings stress the importance of hippocampal aromatase expression in neurodegenerative diseases.
American Psychological Association (APA)
Prange-Kiel, Janine& Dudzinski, Danuta A.& Pröls, Felicitas& Glatzel, Markus& Matschke, Jakob& Rune, Gabriele M.. 2016. Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice. Neural Plasticity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113397
Modern Language Association (MLA)
Prange-Kiel, Janine…[et al.]. Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice. Neural Plasticity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113397
American Medical Association (AMA)
Prange-Kiel, Janine& Dudzinski, Danuta A.& Pröls, Felicitas& Glatzel, Markus& Matschke, Jakob& Rune, Gabriele M.. Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113397
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113397