Effect of Associative Learning on Memory Spine Formation in Mouse Barrel Cortex
Joint Authors
Kossut, Małgorzata
Litwin, Jan A.
Jasek, Ewa
Jasinska, Malgorzata
Siucinska, Ewa
Pyza, Elzbieta
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Associative fear learning, in which stimulation of whiskers is paired with mild electric shock to the tail, modifies the barrel cortex, the functional representation of sensory receptors involved in the conditioning, by inducing formation of new inhibitory synapses on single-synapse spines of the cognate barrel hollows and thus producing double-synapse spines.
In the barrel cortex of conditioned, pseudoconditioned, and untreated mice, we analyzed the number and morphological features of dendritic spines at various maturation and stability levels: sER-free spines, spines containing smooth endoplasmic reticulum (sER), and spines containing spine apparatus.
Using stereological analysis of serial sections examined by transmission electron microscopy, we found that the density of double-synapse spines containing spine apparatus was significantly increased in the conditioned mice.
Learning also induced enhancement of the postsynaptic density area of inhibitory synapses as well as increase in the number of polyribosomes in such spines.
In single-synapse spines, the effects of conditioning were less pronounced and included increase in the number of polyribosomes in sER-free spines.
The results suggest that fear learning differentially affects single- and double-synapse spines in the barrel cortex: it promotes maturation and stabilization of double-synapse spines, which might possibly contribute to permanent memory formation, and upregulates protein synthesis in single-synapse spines.
American Psychological Association (APA)
Jasinska, Malgorzata& Siucinska, Ewa& Jasek, Ewa& Litwin, Jan A.& Pyza, Elzbieta& Kossut, Małgorzata. 2015. Effect of Associative Learning on Memory Spine Formation in Mouse Barrel Cortex. Neural Plasticity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113406
Modern Language Association (MLA)
Jasinska, Malgorzata…[et al.]. Effect of Associative Learning on Memory Spine Formation in Mouse Barrel Cortex. Neural Plasticity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113406
American Medical Association (AMA)
Jasinska, Malgorzata& Siucinska, Ewa& Jasek, Ewa& Litwin, Jan A.& Pyza, Elzbieta& Kossut, Małgorzata. Effect of Associative Learning on Memory Spine Formation in Mouse Barrel Cortex. Neural Plasticity. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113406
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113406