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Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons
Joint Authors
Cisternas, Pedro
Salazar, Paulina
Silva-Álvarez, Carmen
Barros, L. Felipe
Inestrosa, Nibaldo C.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-05
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In the last few years, several reports have proposed that Wnt signaling is a general metabolic regulator, suggesting a role for this pathway in the control of metabolic flux.
Wnt signaling is critical for several neuronal functions, but little is known about the correlation between this pathway and energy metabolism.
The brain has a high demand for glucose, which is mainly used for energy production.
Neurons use energy for highly specific processes that require a high energy level, such as maintaining the electrical potential and synthesizing neurotransmitters.
Moreover, an important metabolic impairment has been described in all neurodegenerative disorders.
Despite the key role of glucose metabolism in the brain, little is known about the cellular pathways involved in regulating this process.
We report here that Wnt5a induces an increase in glucose uptake and glycolytic rate and an increase in the activity of the pentose phosphate pathway; the effects of Wnt5a require the intracellular generation of nitric oxide.
Our data suggest that Wnt signaling stimulates neuronal glucose metabolism, an effect that could be important for the reported neuroprotective role of Wnt signaling in neurodegenerative disorders.
American Psychological Association (APA)
Cisternas, Pedro& Salazar, Paulina& Silva-Álvarez, Carmen& Barros, L. Felipe& Inestrosa, Nibaldo C.. 2016. Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons. Neural Plasticity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113414
Modern Language Association (MLA)
Cisternas, Pedro…[et al.]. Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons. Neural Plasticity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1113414
American Medical Association (AMA)
Cisternas, Pedro& Salazar, Paulina& Silva-Álvarez, Carmen& Barros, L. Felipe& Inestrosa, Nibaldo C.. Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113414
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113414