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Protective Effect of PPARγ Agonists on Cerebellar Tissues Oxidative Damage in Hypothyroid Rats
Joint Authors
Baghcheghi, Yousef
Beheshti, Farimah
Salmani, Hossein
Soukhtanloo, Mohammad
Hosseini, Mahmoud
Source
Neurology Research International
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of the current study was to investigate the effects of peroxisome proliferator-activated receptor gamma (PPARγ) agonists on cerebellar tissues oxidative damage in hypothyroid rats.
The animals included seven groups: group I (control), the animals received drinking water; group II, the animals received 0.05% propylthiouracil (PTU) in drinking water; besides PTU, the animals in groups III, IV, V, VI, and VII, were injected with 20 mg/kg vitamin E (Vit E), 10 or 20 mg/kg pioglitazone, and 2 or 4 mg/kg rosiglitazone, respectively.
The animals were deeply anesthetized and the cerebellar tissues were removed for biochemical measurements.
PTU administration reduced thiol content, superoxide dismutase (SOD), and catalase (CAT) activities in the cerebellar tissues while increasing malondialdehyde (MDA) and nitric oxide (NO) metabolites.
Vit E, pioglitazone, and rosiglitazone increased thiol, SOD, and CAT in the cerebellar tissues while reducing MDA and NO metabolites.
The results of present study showed that, similar to Vit E, both rosiglitazone and pioglitazone as PPARγ agonists exerted protective effects against cerebellar tissues oxidative damage in hypothyroid rats.
American Psychological Association (APA)
Baghcheghi, Yousef& Beheshti, Farimah& Salmani, Hossein& Soukhtanloo, Mohammad& Hosseini, Mahmoud. 2016. Protective Effect of PPARγ Agonists on Cerebellar Tissues Oxidative Damage in Hypothyroid Rats. Neurology Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113425
Modern Language Association (MLA)
Baghcheghi, Yousef…[et al.]. Protective Effect of PPARγ Agonists on Cerebellar Tissues Oxidative Damage in Hypothyroid Rats. Neurology Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113425
American Medical Association (AMA)
Baghcheghi, Yousef& Beheshti, Farimah& Salmani, Hossein& Soukhtanloo, Mohammad& Hosseini, Mahmoud. Protective Effect of PPARγ Agonists on Cerebellar Tissues Oxidative Damage in Hypothyroid Rats. Neurology Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113425
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113425