Plasma Markers of Oxidative Stress in Patients with Gestational Diabetes Mellitus in the Second and Third Trimester
Joint Authors
Li, Hongwei
Yin, Qian
Li, Ning
Ouyang, Zhenbo
Zhong, Mei
Source
Obstetrics and Gynecology International
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To determine plasma markers of oxidative stress during the second and third trimester of pregnancy in patients with gestational diabetes mellitus (GDM).
Study Design.
We conducted a prospective nested case-control study involving 400 pregnant women, 22 of whom developed GDM.
As control group, 30 normal pregnant women were chosen randomly.
Plasma samples were analyzed for 8-iso-prostaglandin F2α (8-iso-PGF2α), advanced oxidative protein products (AOPPs), protein carbonyl (PCO), glutathione peroxidase-3 (GPX-3), and paraoxonase-1 (PON1) at 16–20 weeks, 24–28 weeks, and 32–36 weeks of gestation.
Results.
Compared to control subjects, the plasma levels of PCO, AOPPs, and 8-iso-PGF2α were elevated at 16–20 weeks’ and 32–36 weeks’ gestation in GDM.
There was no significant difference in PCO and 8-iso-PGF2α at 24–28 weeks in GDM.
GPX-3 was statistically significantly increased at 16–20 weeks and 32–36 weeks in GDM.
PON1 reduced in patients with GDM.
No significant differences were found at 24–28 and 32–36 weeks between the GDM and control groups.
In GDM, PCO, AOPPs, and 8-iso-PGF2α levels were higher and GPX-3 and PON1 levels were lower in the second than the third trimester.
Conclusion.
Oxidation status increased in GDM, especially protein oxidation, which may contribute to the pathogenesis of GDM.
American Psychological Association (APA)
Li, Hongwei& Yin, Qian& Li, Ning& Ouyang, Zhenbo& Zhong, Mei. 2016. Plasma Markers of Oxidative Stress in Patients with Gestational Diabetes Mellitus in the Second and Third Trimester. Obstetrics and Gynecology International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113496
Modern Language Association (MLA)
Li, Hongwei…[et al.]. Plasma Markers of Oxidative Stress in Patients with Gestational Diabetes Mellitus in the Second and Third Trimester. Obstetrics and Gynecology International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1113496
American Medical Association (AMA)
Li, Hongwei& Yin, Qian& Li, Ning& Ouyang, Zhenbo& Zhong, Mei. Plasma Markers of Oxidative Stress in Patients with Gestational Diabetes Mellitus in the Second and Third Trimester. Obstetrics and Gynecology International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113496
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113496