Clinicopathological Significance of Vimentin and Cytokeratin Protein in the Genesis of Squamous Cell Carcinoma of Cervix
Joint Authors
Yahia Babiker, Ali Yousif
Rahmani, Arshad H.
Aly, Salah M.
Husain, Nazik Elmalaika O. S.
Albutti, Aqel S.
Alsahli, Mohammed A.
Source
Obstetrics and Gynecology International
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Cervical cancer is one of the commonest types of cancers worldwide especially in developing countries.
Intermediate filaments protein family has shown a role in the diagnosis of various cancers, but a few studies are available about the vimentin and cytokeratin roles in the cervical cancer.
This case control study aimed to interpret the expression of vimentin and cytokeratin proteins in the development and progression of cervical cancer and its correlation with clinicopathological features.
The cytoplasmic expression of vimentin was observed in 40% of cases, but not in inflammatory lesions of cervix.
It was noticed that vimentin expression was increasing significantly with high grade of the tumour.
Cytokeratin expression was observed in 48.33% and it was noticed that the expression was 62.5% in well differentiated (G1), 45% in moderately differentiated (G2), and 41.66% in poorly differentiated carcinoma, yet statistically insignificant.
The expression of vimentin and cytokeratin proteins was not significantly associated with age groups.
The current findings concluded a possible role of vimentin in the development and progression of cervical cancer and vimentin marker will be useful in the diagnosis and grading of cervical cancer.
American Psychological Association (APA)
Husain, Nazik Elmalaika O. S.& Yahia Babiker, Ali Yousif& Albutti, Aqel S.& Alsahli, Mohammed A.& Aly, Salah M.& Rahmani, Arshad H.. 2016. Clinicopathological Significance of Vimentin and Cytokeratin Protein in the Genesis of Squamous Cell Carcinoma of Cervix. Obstetrics and Gynecology International،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1113510
Modern Language Association (MLA)
Husain, Nazik Elmalaika O. S.…[et al.]. Clinicopathological Significance of Vimentin and Cytokeratin Protein in the Genesis of Squamous Cell Carcinoma of Cervix. Obstetrics and Gynecology International No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1113510
American Medical Association (AMA)
Husain, Nazik Elmalaika O. S.& Yahia Babiker, Ali Yousif& Albutti, Aqel S.& Alsahli, Mohammed A.& Aly, Salah M.& Rahmani, Arshad H.. Clinicopathological Significance of Vimentin and Cytokeratin Protein in the Genesis of Squamous Cell Carcinoma of Cervix. Obstetrics and Gynecology International. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1113510
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113510