The Effects of the Combination of a Refined Carbohydrate Diet and Exposure to Hyperoxia in Mice
Joint Authors
Silva, Marcelo Eustáquio
Talvani, André
Soares, Nicia Pedreira
Campos, Keila Karine Duarte
Pena, Karina Braga
Bandeira, Ana Carla Balthar
Bezerra, Frank Silva
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Obesity is a multifactorial disease with genetic, social, and environmental influences.
This study aims at analyzing the effects of the combination of a refined carbohydrate diet and exposure to hyperoxia on the pulmonary oxidative and inflammatory response in mice.
Twenty-four mice were divided into four groups: control group (CG), hyperoxia group (HG), refined carbohydrate diet group (RCDG), and refined carbohydrate diet + hyperoxia group (RCDHG).
The experimental diet was composed of 10% sugar, 45% standard diet, and 45% sweet condensed milk.
For 24 hours, the HG and RCDHG were exposed to hyperoxia and the CG and RCDG to ambient air.
After the exposures were completed, the animals were euthanized, and blood, bronchoalveolar lavage fluid, and lungs were collected for analyses.
The HG showed higher levels of interferon-γ in adipose tissue as compared to other groups and higher levels of interleukin-10 and tumor necrosis factor-α compared to the CG and RCDHG.
SOD and CAT activities in the pulmonary parenchyma decreased in the RCDHG as compared to the CG.
There was an increase of lipid peroxidation in the HG, RCDG, and RCDHG as compared to the CG.
A refined carbohydrate diet combined with hyperoxia promoted inflammation and redox imbalance in adult mice.
American Psychological Association (APA)
Soares, Nicia Pedreira& Campos, Keila Karine Duarte& Pena, Karina Braga& Bandeira, Ana Carla Balthar& Talvani, André& Silva, Marcelo Eustáquio…[et al.]. 2016. The Effects of the Combination of a Refined Carbohydrate Diet and Exposure to Hyperoxia in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113579
Modern Language Association (MLA)
Soares, Nicia Pedreira…[et al.]. The Effects of the Combination of a Refined Carbohydrate Diet and Exposure to Hyperoxia in Mice. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113579
American Medical Association (AMA)
Soares, Nicia Pedreira& Campos, Keila Karine Duarte& Pena, Karina Braga& Bandeira, Ana Carla Balthar& Talvani, André& Silva, Marcelo Eustáquio…[et al.]. The Effects of the Combination of a Refined Carbohydrate Diet and Exposure to Hyperoxia in Mice. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113579
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113579