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Role of ROS and RNS Sources in Physiological and Pathological Conditions
Joint Authors
Venditti, P.
Victor, Victor M.
Di Meo, Sergio
Reed, Tanea T.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-44, 44 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-12
Country of Publication
Egypt
No. of Pages
44
Main Subjects
Abstract EN
There is significant evidence that, in living systems, free radicals and other reactive oxygen and nitrogen species play a double role, because they can cause oxidative damage and tissue dysfunction and serve as molecular signals activating stress responses that are beneficial to the organism.
Mitochondria have been thought to both play a major role in tissue oxidative damage and dysfunction and provide protection against excessive tissue dysfunction through several mechanisms, including stimulation of opening of permeability transition pores.
Until recently, the functional significance of ROS sources different from mitochondria has received lesser attention.
However, the most recent data, besides confirming the mitochondrial role in tissue oxidative stress and protection, show interplay between mitochondria and other ROS cellular sources, so that activation of one can lead to activation of other sources.
Thus, it is currently accepted that in various conditions all cellular sources of ROS provide significant contribution to processes that oxidatively damage tissues and assure their survival, through mechanisms such as autophagy and apoptosis.
American Psychological Association (APA)
Di Meo, Sergio& Reed, Tanea T.& Venditti, P.& Victor, Victor M.. 2016. Role of ROS and RNS Sources in Physiological and Pathological Conditions. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-44.
https://search.emarefa.net/detail/BIM-1113599
Modern Language Association (MLA)
Di Meo, Sergio…[et al.]. Role of ROS and RNS Sources in Physiological and Pathological Conditions. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-44.
https://search.emarefa.net/detail/BIM-1113599
American Medical Association (AMA)
Di Meo, Sergio& Reed, Tanea T.& Venditti, P.& Victor, Victor M.. Role of ROS and RNS Sources in Physiological and Pathological Conditions. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-44.
https://search.emarefa.net/detail/BIM-1113599
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113599