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The Nutraceutical Dehydrozingerone and Its Dimer Counteract Inflammation- and Oxidative Stress-Induced Dysfunction of In Vitro Cultured Human Endothelial Cells: A Novel Perspective for the Prevention and Therapy of Atherosclerosis
Joint Authors
Buttari, Brigitta
D’Arcangelo, Daniela
Tinaburri, Lavinia
Dettori, Maria Antonietta
Fabbri, Davide
Delogu, Giovanna
Riganò, Rachele
Profumo, Elisabetta
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Atherosclerosis is characterized by endothelial dysfunction, mainly induced by inflammation and oxidative stress.
Increased reactive oxygen species (ROS) production together with increased adhesion molecules and thrombogenic tissue factor (TF) expression on endothelial cells has a key role in proatherogenic mechanisms.
Therefore downmodulation of these molecules could be useful for reducing the severity of inflammation and atherosclerosis progression.
Dehydrozingerone (DHZ) is a nutraceutical compound with anti-inflammatory and antioxidant activities.
In this study we evaluated the ability of DHZ and its symmetric dimer to modulate hydrogen peroxide- (H2O2-) induced ROS production in human umbilical vein endothelial cells (HUVEC).
We also evaluated intercellular adhesion molecule- (ICAM-) 1, vascular cell adhesion molecule- (VCAM-) 1, and TF expression in HUVEC activated by tumor necrosis factor- (TNF-) α.
HUVEC pretreatment with DHZ and DHZ dimer reduced H2O2-induced ROS production and inhibited adhesion molecule expression and secretion.
Of note, only DHZ dimer was able to reduce TF expression.
DHZ effects were in part mediated by the inhibition of the nuclear factor- (NF-) κB activation.
Overall, our findings demonstrate that the DHZ dimer exerts a potent anti-inflammatory, antioxidant, and antithrombotic activity on endothelial cells and suggest potential usefulness of this compound to contrast the pathogenic mechanisms involved in atherosclerosis progression.
American Psychological Association (APA)
Profumo, Elisabetta& Buttari, Brigitta& D’Arcangelo, Daniela& Tinaburri, Lavinia& Dettori, Maria Antonietta& Fabbri, Davide…[et al.]. 2016. The Nutraceutical Dehydrozingerone and Its Dimer Counteract Inflammation- and Oxidative Stress-Induced Dysfunction of In Vitro Cultured Human Endothelial Cells: A Novel Perspective for the Prevention and Therapy of Atherosclerosis. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113600
Modern Language Association (MLA)
Profumo, Elisabetta…[et al.]. The Nutraceutical Dehydrozingerone and Its Dimer Counteract Inflammation- and Oxidative Stress-Induced Dysfunction of In Vitro Cultured Human Endothelial Cells: A Novel Perspective for the Prevention and Therapy of Atherosclerosis. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113600
American Medical Association (AMA)
Profumo, Elisabetta& Buttari, Brigitta& D’Arcangelo, Daniela& Tinaburri, Lavinia& Dettori, Maria Antonietta& Fabbri, Davide…[et al.]. The Nutraceutical Dehydrozingerone and Its Dimer Counteract Inflammation- and Oxidative Stress-Induced Dysfunction of In Vitro Cultured Human Endothelial Cells: A Novel Perspective for the Prevention and Therapy of Atherosclerosis. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113600