Neuroprotective Effects of Isosteviol Sodium Injection on Acute Focal Cerebral Ischemia in Rats
Joint Authors
Hu, Hui
Sun, Xiao ou
Tian, Fang
Zhang, Hao
Liu, Qing
Tan, Wen
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Previous report has indicated that isosteviol has neuroprotective effects.
However, isosteviol was administered preventively before ischemia and the inclusion criteria were limited.
In the present study, a more soluble and injectable form of isosteviol sodium (STVNA) was administered intravenously hours after transient or permanent middle cerebral artery occlusion (tMCAO or pMCAO) to investigate its neuroprotective effects in rats.
The rats were assessed for neurobehavioral deficits 24 hours after ischemia and sacrificed for infarct volume quantification and histology evaluation.
STVNA 10 mg·kg−1 can significantly reduce the infarct volumes compared with vehicle in animals subjected to tMCAO and is twice as potent as previously reported.
Additionally, the therapeutic window study showed that STVNA could reduce the infarct volume compared with the vehicle group when administered 4 hours after reperfusion.
A similar effect was also observed in animals treated 4 hours after pMCAO.
Assessment of neurobehavioral deficits after 24 hours showed that STVNA treatment significantly reduced neurobehavioral impairments.
The number of restored NeuN-labeled neurons was increased and the number of TUNEL positive cells was reduced in animals that received STVNA treatment compared with vehicle group.
All of these findings suggest that STVNA might provide therapeutic benefits against cerebral ischemia-induced injury.
American Psychological Association (APA)
Hu, Hui& Sun, Xiao ou& Tian, Fang& Zhang, Hao& Liu, Qing& Tan, Wen. 2016. Neuroprotective Effects of Isosteviol Sodium Injection on Acute Focal Cerebral Ischemia in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113607
Modern Language Association (MLA)
Hu, Hui…[et al.]. Neuroprotective Effects of Isosteviol Sodium Injection on Acute Focal Cerebral Ischemia in Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113607
American Medical Association (AMA)
Hu, Hui& Sun, Xiao ou& Tian, Fang& Zhang, Hao& Liu, Qing& Tan, Wen. Neuroprotective Effects of Isosteviol Sodium Injection on Acute Focal Cerebral Ischemia in Rats. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113607