Antioxidant, Antibacterial, and Cytotoxic Activities of the Ethanolic Origanum vulgare Extract and Its Major Constituents
Joint Authors
Coccimiglio, John
Alipour, Misagh
Jiang, Zi-Hua
Gottardo, Christine
Suntres, Zacharias
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Oregano is a perennial shrub that grows in the mountains of the Mediterranean and Euro/Irano-Siberian regions.
This study was conducted to identify the major constituents of the ethanolic Origanum vulgare extract and examine the cytotoxic, antioxidant, and antibacterial properties of the extract but more importantly the contribution of its specific major constituent(s) or their combination to the overall extract biological activity.
Gas chromatography/mass spectroscopy analysis showed that the extract contained monoterpene hydrocarbons and phenolic compounds, the major ones being carvacrol and thymol and to a lesser extent p-cymene, 1-octacosanol, creosol, and phytol.
A549 epithelial cells challenged with the extract showed a concentration-dependent increase in cytotoxicity.
A combination of thymol and carvacrol at equimolar concentrations to those present in the extract was less cytotoxic.
The A549 cells pretreated with nonlethal extract concentrations protected against hydrogen-peroxide-induced cytotoxicity, an antioxidant effect more effective than the combination of equimolar concentrations of thymol/carvacrol.
Inclusion of p-cymene and/or 1-octacosanol did not alter the synergistic antioxidant effects of the carvacrol/thymol mixture.
The extract also exhibited antimicrobial properties against Gram-positive and Gram-negative bacterial strains including clinical isolates.
In conclusion, the oregano extract has cytotoxic, antioxidant, and antibacterial activities mostly attributed to carvacrol and thymol.
American Psychological Association (APA)
Coccimiglio, John& Alipour, Misagh& Jiang, Zi-Hua& Gottardo, Christine& Suntres, Zacharias. 2016. Antioxidant, Antibacterial, and Cytotoxic Activities of the Ethanolic Origanum vulgare Extract and Its Major Constituents. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113610
Modern Language Association (MLA)
Coccimiglio, John…[et al.]. Antioxidant, Antibacterial, and Cytotoxic Activities of the Ethanolic Origanum vulgare Extract and Its Major Constituents. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1113610
American Medical Association (AMA)
Coccimiglio, John& Alipour, Misagh& Jiang, Zi-Hua& Gottardo, Christine& Suntres, Zacharias. Antioxidant, Antibacterial, and Cytotoxic Activities of the Ethanolic Origanum vulgare Extract and Its Major Constituents. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113610
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113610