The Protective Effects of Trypsin Inhibitor on Hepatic Ischemia-Reperfusion Injury and Liver Graft Survival
Joint Authors
Guan, Lianyue
Liu, Hongyu
Fu, Peiyao
Li, Zhuonan
Li, Peidong
Xie, Lijuan
Xin, Mingang
Wang, Zhanpeng
Li, Wei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The aim of this study was to explore the protective effects of ulinastatin (urinary trypsin inhibitor, UTI) on liver ischemia-reperfusion injury (IRI) and graft survival.
We employed mouse liver cold IRI and orthotopic liver transplantation (OLTx) models.
UTI was added to lactated Ringer’s (LR) solution for liver perfusion and preservation in vitro or combined with UTI injection intraperitoneally to the liver graft recipient.
Our results indicated that UTI supplementation protected the liver from cold IRI in a dose-dependent manner and prolonged liver graft survival from extended cold preserved liver donors significantly.
The underlying mechanism of UTI on liver IRI may be mediated by inhibition of proinflammatory cytokine release, increasing the expression of the antiapoptotic gene Bcl-2 and decreasing the expression of the proapoptosis genes of Caspase-3 and Bax, and further protects hepatocytes from apoptotic death and improves liver function.
American Psychological Association (APA)
Guan, Lianyue& Liu, Hongyu& Fu, Peiyao& Li, Zhuonan& Li, Peidong& Xie, Lijuan…[et al.]. 2015. The Protective Effects of Trypsin Inhibitor on Hepatic Ischemia-Reperfusion Injury and Liver Graft Survival. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113611
Modern Language Association (MLA)
Guan, Lianyue…[et al.]. The Protective Effects of Trypsin Inhibitor on Hepatic Ischemia-Reperfusion Injury and Liver Graft Survival. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113611
American Medical Association (AMA)
Guan, Lianyue& Liu, Hongyu& Fu, Peiyao& Li, Zhuonan& Li, Peidong& Xie, Lijuan…[et al.]. The Protective Effects of Trypsin Inhibitor on Hepatic Ischemia-Reperfusion Injury and Liver Graft Survival. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113611