Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3KAkt and MAPK Signaling Pathways
Joint Authors
Luo, Yun
Shi, Zhi
Wu, Jie-Ying
Lu, Min-Hua
Na, Ning
Di, Jin-Ming
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
TRPM7 is a potential therapeutic target for treatment of prostate cancer.
In this study, we investigated the effects of nonselective TRPM7 inhibitor carvacrol on cell proliferation, migration, and invasion of prostate cancer PC-3 and DU145 cells.
Our results showed that carvacrol blocked TRPM7-like currents in PC-3 and DU145 cells and reduced their proliferation, migration, and invasion.
Moreover, carvacrol treatment significantly decreased MMP-2, p-Akt, and p-ERK1/2 protein expression and inhibited F-actin reorganization.
Furthermore, consistently, TRPM7 knockdown reduced prostate cancer cell proliferation, migration, and invasion as well.
Our study suggests that carvacrol may have therapeutic potential for the treatment of prostate cancer through its inhibition of TRPM7 channels and suppression of PI3K/Akt and MAPK signaling pathways.
American Psychological Association (APA)
Luo, Yun& Wu, Jie-Ying& Lu, Min-Hua& Shi, Zhi& Na, Ning& Di, Jin-Ming. 2016. Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3KAkt and MAPK Signaling Pathways. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113614
Modern Language Association (MLA)
Luo, Yun…[et al.]. Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3KAkt and MAPK Signaling Pathways. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113614
American Medical Association (AMA)
Luo, Yun& Wu, Jie-Ying& Lu, Min-Hua& Shi, Zhi& Na, Ning& Di, Jin-Ming. Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3KAkt and MAPK Signaling Pathways. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113614
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113614
