Reactive Oxygen Species Regulate T Cell Immune Response in the Tumor Microenvironment
Joint Authors
Zhang, Bin
Zhang, Yi
Chen, Xinfeng
Song, Mengjia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Reactive oxygen species (ROS) produced by cellular metabolism play an important role as signaling messengers in immune system.
ROS elevated in the tumor microenvironment are associated with tumor-induced immunosuppression.
T cell-based therapy has been recently approved to be effective for cancer treatment.
However, T cells often become dysfunctional after reaching the tumor site.
It has been reported that ROS participate extensively in T cells activation, apoptosis, and hyporesponsiveness.
The sensitivity of T cells to ROS varies among different subsets.
ROS can be regulated by cytokines, amino acid metabolism, and enzymatic activity.
Immunosuppressive cells accumulate in the tumor microenvironment and induce apoptosis and functional suppression of T cells by producing ROS.
Thus, modulating the level of ROS may be important to prolong survival of T cells and enhance their antitumor function.
Combining T cell-based therapy with antioxidant treatment such as administration of ROS scavenger should be considered as a promising strategy in cancer treatment, aiming to improve antitumor T cells immunity.
American Psychological Association (APA)
Chen, Xinfeng& Song, Mengjia& Zhang, Bin& Zhang, Yi. 2016. Reactive Oxygen Species Regulate T Cell Immune Response in the Tumor Microenvironment. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113631
Modern Language Association (MLA)
Chen, Xinfeng…[et al.]. Reactive Oxygen Species Regulate T Cell Immune Response in the Tumor Microenvironment. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113631
American Medical Association (AMA)
Chen, Xinfeng& Song, Mengjia& Zhang, Bin& Zhang, Yi. Reactive Oxygen Species Regulate T Cell Immune Response in the Tumor Microenvironment. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113631
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113631