Reactive Oxygen Species and Targeted Therapy for Pancreatic Cancer
Joint Authors
Li, Xuqi
Ma, Qingyong
Zhang, Lun
Zong, Liang
Li, Jiahui
Jiang, Zhengdong
Chen, Xin
Chen, Ke
Nan, Ligang
Li, Wei
Shan, Tao
Ma, Zhenhua
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Pancreatic cancer is the fourth leading cause of cancer-related death in the United States.
Reactive oxygen species (ROS) are generally increased in pancreatic cancer cells compared with normal cells.
ROS plays a vital role in various cellular biological activities including proliferation, growth, apoptosis, and invasion.
Besides, ROS participates in tumor microenvironment orchestration.
The role of ROS is a doubled-edged sword in pancreatic cancer.
The dual roles of ROS depend on the concentration.
ROS facilitates carcinogenesis and cancer progression with mild-to-moderate elevated levels, while excessive ROS damages cancer cells dramatically and leads to cell death.
Based on the recent knowledge, either promoting ROS generation to increase the concentration of ROS with extremely high levels or enhancing ROS scavenging ability to decrease ROS levels may benefit the treatment of pancreatic cancer.
However, when faced with oxidative stress, the antioxidant programs of cancer cells have been activated to help cancer cells to survive in the adverse condition.
Furthermore, ROS signaling and antioxidant programs play the vital roles in the progression of pancreatic cancer and in the response to cancer treatment.
Eventually, it may be the novel target for various strategies and drugs to modulate ROS levels in pancreatic cancer therapy.
American Psychological Association (APA)
Zhang, Lun& Li, Jiahui& Zong, Liang& Chen, Xin& Chen, Ke& Jiang, Zhengdong…[et al.]. 2016. Reactive Oxygen Species and Targeted Therapy for Pancreatic Cancer. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113635
Modern Language Association (MLA)
Zhang, Lun…[et al.]. Reactive Oxygen Species and Targeted Therapy for Pancreatic Cancer. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113635
American Medical Association (AMA)
Zhang, Lun& Li, Jiahui& Zong, Liang& Chen, Xin& Chen, Ke& Jiang, Zhengdong…[et al.]. Reactive Oxygen Species and Targeted Therapy for Pancreatic Cancer. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113635
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113635