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Berberine Attenuates Myocardial IschemiaReperfusion Injury by Reducing Oxidative Stress and Inflammation Response: Role of Silent Information Regulator 1
Joint Authors
Yu, Liming
Li, Qing
Yu, Bo
Yang, Yang
Jin, Zhenxiao
Duan, Weixun
Zhao, Guolong
Zhai, Mengen
Liu, Lijun
Yi, Dinghua
Chen, Min
Yu, Shiqiang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-14
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Berberine (BBR) exerts potential protective effect against myocardial ischemia/reperfusion (MI/R) injury.
Activation of silent information regulator 1 (SIRT1) signaling attenuates MI/R injury by reducing oxidative damage and inflammation response.
This study investigated the antioxidative and anti-inflammatory effects of BBR treatment in MI/R condition and elucidated its potential mechanisms.
Sprague-Dawley rats were treated with BBR in the absence or presence of the SIRT1 inhibitor sirtinol (Stnl) and then subjected to MI/R injury.
BBR conferred cardioprotective effects by improving postischemic cardiac function, decreasing infarct size, reducing apoptotic index, diminishing serum creatine kinase and lactate dehydrogenase levels, upregulating SIRT1, Bcl-2 expressions, and downregulating Bax and caspase-3 expressions.
Stnl attenuated these effects by inhibiting SIRT1 signaling.
BBR treatment also reduced myocardium superoxide generation, gp91phox expression, malondialdehyde (MDA) level, and cardiac inflammatory markers and increased myocardium superoxide dismutase (SOD) level.
However, these effects were also inhibited by Stnl.
Consistently, BBR conferred similar antioxidative and anti-inflammatory effects against simulated ischemia reperfusion injury in cultured H9C2 cardiomyocytes.
SIRT1 siRNA administration also abolished these effects.
In summary, our results demonstrate that BBR significantly improves post-MI/R cardiac function recovery and reduces infarct size against MI/R injury possibly due to its strong antioxidative and anti-inflammatory activity.
Additionally, SIRT1 signaling plays a key role in this process.
American Psychological Association (APA)
Yu, Liming& Li, Qing& Yu, Bo& Yang, Yang& Jin, Zhenxiao& Duan, Weixun…[et al.]. 2015. Berberine Attenuates Myocardial IschemiaReperfusion Injury by Reducing Oxidative Stress and Inflammation Response: Role of Silent Information Regulator 1. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113638
Modern Language Association (MLA)
Yu, Liming…[et al.]. Berberine Attenuates Myocardial IschemiaReperfusion Injury by Reducing Oxidative Stress and Inflammation Response: Role of Silent Information Regulator 1. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1113638
American Medical Association (AMA)
Yu, Liming& Li, Qing& Yu, Bo& Yang, Yang& Jin, Zhenxiao& Duan, Weixun…[et al.]. Berberine Attenuates Myocardial IschemiaReperfusion Injury by Reducing Oxidative Stress and Inflammation Response: Role of Silent Information Regulator 1. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1113638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113638