Bypassing Mechanisms of Mitochondria-Mediated Cancer Stem Cells Resistance to Chemo- and Radiotherapy
Joint Authors
Lyakhovich, Alex
Lleonart, Matilde E.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cancer stem cells (CSCs) are highly resistant to conventional chemo- and radiotherapeutic regimes.
Therefore, the multiple drug resistance (MDR) of cancer is most likely due to the resistance of CSCs.
Such resistance can be attributed to some bypassing pathways including detoxification mechanisms of reactive oxygen and nitrogen species (RO/NS) formation or enhanced autophagy.
Unlike in normal cells, where RO/NS concentration is maintained at certain threshold required for signal transduction or immune response mechanisms, CSCs may develop alternative pathways to diminish RO/NS levels leading to cancer survival.
In this minireview, we will focus on elaborated mechanisms developed by CSCs to attenuate high RO/NS levels.
Gaining a better insight into the mechanisms of stem cell resistance to chemo- or radiotherapy may lead to new therapeutic targets thus serving for better anticancer strategies.
American Psychological Association (APA)
Lyakhovich, Alex& Lleonart, Matilde E.. 2015. Bypassing Mechanisms of Mitochondria-Mediated Cancer Stem Cells Resistance to Chemo- and Radiotherapy. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113640
Modern Language Association (MLA)
Lyakhovich, Alex& Lleonart, Matilde E.. Bypassing Mechanisms of Mitochondria-Mediated Cancer Stem Cells Resistance to Chemo- and Radiotherapy. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113640
American Medical Association (AMA)
Lyakhovich, Alex& Lleonart, Matilde E.. Bypassing Mechanisms of Mitochondria-Mediated Cancer Stem Cells Resistance to Chemo- and Radiotherapy. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113640
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113640