Change in Free Radical and Antioxidant Enzyme Levels in the Patients Undergoing Open Heart Surgery with Cardiopulmonary Bypass
Joint Authors
Türker, Fevzi Sarper
Doğan, Ayşe
Ozan, Gonca
Kıbar, Kurtuluş
Erışır, Mine
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
The purpose of this study is to determine the changes in oxidative damage and antioxidant parameters in open heart surgeries with cardiopulmonary bypass (CPB) in preoperative and early postoperative periods.
Methods.
A total of three consecutive arterial blood samples were obtained from the patients in the study group, in preoperative, early postoperative, and postoperative periods, respectively.
Oxidative damage indicator (MDA) and antioxidant indicators (GPx, GSH, CAT, and SOD) were examined.
Results.
A statistically significant increase was observed in MDA level in postoperative period compared to preoperative and early postoperative periods.
GSH levels and CAT activities increased significantly in early postoperative and postoperative periods.
Analyses revealed an increase in GPx and SOD enzyme activities only in the postoperative period.
Conclusion.
Even though the increase in MDA level was suppressed by the increased GSH level and CAT activity like in early postoperative period, efficiency can be brought for the increases in insufficient significant antioxidant parameters in postoperative period by administering antioxidant supplements to the patients and thus the increase in MDA in postoperative period can be significantly suppressed.
American Psychological Association (APA)
Türker, Fevzi Sarper& Doğan, Ayşe& Ozan, Gonca& Kıbar, Kurtuluş& Erışır, Mine. 2016. Change in Free Radical and Antioxidant Enzyme Levels in the Patients Undergoing Open Heart Surgery with Cardiopulmonary Bypass. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1113645
Modern Language Association (MLA)
Türker, Fevzi Sarper…[et al.]. Change in Free Radical and Antioxidant Enzyme Levels in the Patients Undergoing Open Heart Surgery with Cardiopulmonary Bypass. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1113645
American Medical Association (AMA)
Türker, Fevzi Sarper& Doğan, Ayşe& Ozan, Gonca& Kıbar, Kurtuluş& Erışır, Mine. Change in Free Radical and Antioxidant Enzyme Levels in the Patients Undergoing Open Heart Surgery with Cardiopulmonary Bypass. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1113645
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113645