The Early Effect of Carotid Artery Stenting on Antioxidant Capacity and Oxidative Stress in Patients with Carotid Artery Stenosis
Joint Authors
Wysocka, Ewa
Michalak, Slawomir
Ambrosius, Wojciech
Kozubski, Wojciech
Dziarmaga, Mieczyslaw
Juszkat, Robert
Wykretowicz, Andrzej
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The treatment of carotid artery stenosis is associated with the risk of complications, which may include stroke after carotid artery stenting (CAS) and myocardial infarction after carotid endarterectomy (CEA).
The imbalance between prooxidative mechanisms and antioxidant capacity creates a milieu of factors, which may increase the risk of complications after endovascular procedures.
We have examined 43 consecutive patients with carotid artery stenosis.
Sera were analyzed for the activity of paraoxonase (PON) and arylesterase (ARE), sulfhydryl groups (SG), malondialdehyde (MDA), and conjugated dienes (CD) concentrations by means of spectrophotometric methods before and next day after CAS.
We have found lowered PON (P=0.0032), increase in ARE activity (P=0.0058), and decrease in sulfhydryl groups concentration (P=0.0267).
No effect on absolute MDA and CD concentrations was observed.
The degree of carotid artery stenosis correlated negatively with PON/ARE ratio after CAS (rS = −0.507, P=0.0268).
To conclude, CAS influences both enzymatic (differently, PON and ARE activity) and nonenzymatic antioxidant defense.
Females are more susceptible to lipid peroxidation after CAS.
PON/ARE ratio after CAS correlated with the degree of carotid artery stenosis.
The changes (deltas) in ARE activity, SG, and MDA concentrations correlated with the severity of neurological deficit and disability.
American Psychological Association (APA)
Michalak, Slawomir& Ambrosius, Wojciech& Wysocka, Ewa& Dziarmaga, Mieczyslaw& Juszkat, Robert& Wykretowicz, Andrzej…[et al.]. 2016. The Early Effect of Carotid Artery Stenting on Antioxidant Capacity and Oxidative Stress in Patients with Carotid Artery Stenosis. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113646
Modern Language Association (MLA)
Michalak, Slawomir…[et al.]. The Early Effect of Carotid Artery Stenting on Antioxidant Capacity and Oxidative Stress in Patients with Carotid Artery Stenosis. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1113646
American Medical Association (AMA)
Michalak, Slawomir& Ambrosius, Wojciech& Wysocka, Ewa& Dziarmaga, Mieczyslaw& Juszkat, Robert& Wykretowicz, Andrzej…[et al.]. The Early Effect of Carotid Artery Stenting on Antioxidant Capacity and Oxidative Stress in Patients with Carotid Artery Stenosis. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113646
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113646