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Tissue Kallikrein Alleviates Cerebral Ischemia-Reperfusion Injury by Activating the B2R-ERK12-CREB-Bcl-2 Signaling Pathway in Diabetic Rats
Joint Authors
Liu, Xinfeng
Shi, Ruifeng
Yuan, Kunxiong
Hu, Bin
Sang, Hongfei
Zhou, Lizhi
Xie, Yi
Xu, Lili
Cao, Qinqin
Chen, Xin
Zhao, Lingling
Liu, Ling
Zhang, Renliang
Xiong, Yun Yun
Xu, Gelin
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-30
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Diabetes mellitus (DM) substantially increases the risk of ischemic stroke and reduces the tolerance to ischemic insults.
Tissue kallikrein (TK) has been demonstrated to protect neurons from ischemia/reperfusion (I/R) injury in orthoglycemic model by activating the bradykinin B2 receptor (B2R).
Considering the differential effects of B2R or bradykinin B1 receptor (B1R) on cardioprotection and neuroprotection in I/R with or without diabetes, this study was designed to investigate the role of TK during cerebral I/R injury in streptozotocin-induced diabetic rats.
Intravenous injection of TK inhibited apoptosis in neurons, alleviated edema and inflammatory reactions after focal cerebral I/R, significantly reduced the infarct volume, and improved functional recovery.
These beneficial effects were accompanied by activation of the extracellular signal-regulated kinase 1/2 (ERK1/2), cAMP response element-binding (CREB), and Bcl-2 signal proteins.
Inhibition of the B2R or ERK1/2 pathway abated the effects of TK, whereas an antagonist of B1R enhanced the effects.
These findings reveal that the neuroprotective effect of TK against cerebral I/R injury in streptozotocin-induced diabetic rats mainly involves the enhancement of B2R and ERK1/2-CREB-Bcl-2 signaling pathway activity.
American Psychological Association (APA)
Shi, Ruifeng& Yuan, Kunxiong& Hu, Bin& Sang, Hongfei& Zhou, Lizhi& Xie, Yi…[et al.]. 2016. Tissue Kallikrein Alleviates Cerebral Ischemia-Reperfusion Injury by Activating the B2R-ERK12-CREB-Bcl-2 Signaling Pathway in Diabetic Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113652
Modern Language Association (MLA)
Shi, Ruifeng…[et al.]. Tissue Kallikrein Alleviates Cerebral Ischemia-Reperfusion Injury by Activating the B2R-ERK12-CREB-Bcl-2 Signaling Pathway in Diabetic Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1113652
American Medical Association (AMA)
Shi, Ruifeng& Yuan, Kunxiong& Hu, Bin& Sang, Hongfei& Zhou, Lizhi& Xie, Yi…[et al.]. Tissue Kallikrein Alleviates Cerebral Ischemia-Reperfusion Injury by Activating the B2R-ERK12-CREB-Bcl-2 Signaling Pathway in Diabetic Rats. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113652
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113652