Protective Effects of Carvedilol and Vitamin C against Azithromycin-Induced Cardiotoxicity in Rats via Decreasing ROS, IL1-β, and TNF-α Production and Inhibiting NF-κB and Caspase-3 Expression
Joint Authors
El-Shitany, Nagla A.
El-Desoky, Karema
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-05
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
The Food and Drug Administration recently warned of the fatal cardiovascular risks of azithromycin in humans.
In addition, a recently published study documented azithromycin-induced cardiotoxicity in rats.
This study aimed to justify the exact cardiovascular events accompanying azithromycin administration in rats, focusing on electrocardiographic, biochemical, and histopathological changes.
In addition, the underlying mechanisms were studied regarding reactive oxygen species production, cytokine release, and apoptotic cell-death.
Finally, the supposed protective effects of both carvedilol and vitamin C were assessed.
Four groups of rats were used: (1) control, (2) azithromycin, (3) azithromycin + carvedilol, and (4) azithromycin + vitamin C.
Azithromycin resulted in marked atrophy of cardiac muscle fibers and electrocardiographic segment alteration.
It increased the heart rate, lactate dehydrogenase, creatine phosphokinase, malondialdehyde, nitric oxide, interleukin-1 beta (IL1-β), tumor necrosis factor alpha (TNF-α), nuclear factor kappa beta (NF-κB), and caspase-3.
It decreased reduced glutathione, glutathione peroxidase, and superoxide dismutase.
Carvedilol and vitamin C prevented most of the azithromycin-induced electrocardiographic and histopathological changes.
Carvedilol and vitamin C decreased lactate dehydrogenase, malondialdehyde, IL1-β, TNF-α, NF-κB, and caspase-3.
Both agents increased glutathione peroxidase.
This study shows that both carvedilol and vitamin C protect against azithromycin-induced cardiotoxicity through antioxidant, immunomodulatory, and antiapoptotic mechanisms.
American Psychological Association (APA)
El-Shitany, Nagla A.& El-Desoky, Karema. 2016. Protective Effects of Carvedilol and Vitamin C against Azithromycin-Induced Cardiotoxicity in Rats via Decreasing ROS, IL1-β, and TNF-α Production and Inhibiting NF-κB and Caspase-3 Expression. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113654
Modern Language Association (MLA)
El-Shitany, Nagla A.& El-Desoky, Karema. Protective Effects of Carvedilol and Vitamin C against Azithromycin-Induced Cardiotoxicity in Rats via Decreasing ROS, IL1-β, and TNF-α Production and Inhibiting NF-κB and Caspase-3 Expression. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1113654
American Medical Association (AMA)
El-Shitany, Nagla A.& El-Desoky, Karema. Protective Effects of Carvedilol and Vitamin C against Azithromycin-Induced Cardiotoxicity in Rats via Decreasing ROS, IL1-β, and TNF-α Production and Inhibiting NF-κB and Caspase-3 Expression. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1113654
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113654