1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress
Joint Authors
Velena, Astrida
Zarkovic, Neven
Gall Troselj, Koraljka
Bisenieks, Egils
Krauze, Aivars
Poikans, Janis
Duburs, Gunars
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-35, 35 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
35
Main Subjects
Abstract EN
Many 1,4-dihydropyridines (DHPs) possess redox properties.
In this review DHPs are surveyed as protectors against oxidative stress (OS) and related disorders, considering the DHPs as specific group of potential antioxidants with bioprotective capacities.
They have several peculiarities related to antioxidant activity (AOA).
Several commercially available calcium antagonist, 1,4-DHP drugs, their metabolites, and calcium agonists were shown to express AOA.
Synthesis, hydrogen donor properties, AOA, and methods and approaches used to reveal biological activities of various groups of 1,4-DHPs are presented.
Examples of DHPs antioxidant activities and protective effects of DHPs against OS induced damage in low density lipoproteins (LDL), mitochondria, microsomes, isolated cells, and cell cultures are highlighted.
Comparison of the AOA of different DHPs and other antioxidants is also given.
According to the data presented, the DHPs might be considered as bellwether among synthetic compounds targeting OS and potential pharmacological model compounds targeting oxidative stress important for medicinal chemistry.
American Psychological Association (APA)
Velena, Astrida& Zarkovic, Neven& Gall Troselj, Koraljka& Bisenieks, Egils& Krauze, Aivars& Poikans, Janis…[et al.]. 2016. 1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-35.
https://search.emarefa.net/detail/BIM-1113656
Modern Language Association (MLA)
Velena, Astrida…[et al.]. 1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-35.
https://search.emarefa.net/detail/BIM-1113656
American Medical Association (AMA)
Velena, Astrida& Zarkovic, Neven& Gall Troselj, Koraljka& Bisenieks, Egils& Krauze, Aivars& Poikans, Janis…[et al.]. 1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-35.
https://search.emarefa.net/detail/BIM-1113656
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113656