Molecular and Cellular Effects of Hydrogen Peroxide on Human Lung Cancer Cells: Potential Therapeutic Implications
Joint Authors
Vilema-Enríquez, Gabriela
Arroyo, Aurora
Grijalva, Marcelo
Amador-Zafra, Ricardo Israel
Camacho, Javier
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Lung cancer has a very high mortality-to-incidence ratio, representing one of the main causes of cancer mortality worldwide.
Therefore, new treatment strategies are urgently needed.
Several diseases including lung cancer have been associated with the action of reactive oxygen species (ROS) from which hydrogen peroxide (H2O2) is one of the most studied.
Despite the fact that H2O2 may have opposite effects on cell proliferation depending on the concentration and cell type, it triggers several antiproliferative responses.
H2O2 produces both nuclear and mitochondrial DNA lesions, increases the expression of cell adhesion molecules, and increases p53 activity and other transcription factors orchestrating cancer cell death.
In addition, H2O2 facilitates the endocytosis of oligonucleotides, affects membrane proteins, induces calcium release, and decreases cancer cell migration and invasion.
Furthermore, the MAPK pathway and the expression of genes related to inflammation including interleukins, TNF-α, and NF-κB are also affected by H2O2.
Herein, we will summarize the main effects of hydrogen peroxide on human lung cancer leading to suggesting it as a potential therapeutic tool to fight this disease.
Because of the multimechanistic nature of this molecule, novel therapeutic approaches for lung cancer based on the use of H2O2 may help to decrease the mortality from this malignancy.
American Psychological Association (APA)
Vilema-Enríquez, Gabriela& Arroyo, Aurora& Grijalva, Marcelo& Amador-Zafra, Ricardo Israel& Camacho, Javier. 2016. Molecular and Cellular Effects of Hydrogen Peroxide on Human Lung Cancer Cells: Potential Therapeutic Implications. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113659
Modern Language Association (MLA)
Vilema-Enríquez, Gabriela…[et al.]. Molecular and Cellular Effects of Hydrogen Peroxide on Human Lung Cancer Cells: Potential Therapeutic Implications. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1113659
American Medical Association (AMA)
Vilema-Enríquez, Gabriela& Arroyo, Aurora& Grijalva, Marcelo& Amador-Zafra, Ricardo Israel& Camacho, Javier. Molecular and Cellular Effects of Hydrogen Peroxide on Human Lung Cancer Cells: Potential Therapeutic Implications. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1113659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113659