Diabetes-Induced Oxidative Stress in Endothelial Progenitor Cells May Be Sustained by a Positive Feedback Loop Involving High Mobility Group Box-1
Joint Authors
Xu, Biao
Xie, Jun
Wu, Han
Li, Ran
Wei, Zhong-Hai
Zhang, Xin-Lin
Chen, Jian-Zhou
Dai, Qing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Oxidative stress is considered to be a critical factor in diabetes-induced endothelial progenitor cell (EPC) dysfunction, although the underlying mechanisms are not fully understood.
In this study, we investigated the role of high mobility group box-1 (HMGB-1) in diabetes-induced oxidative stress.
HMGB-1 was upregulated in both serum and bone marrow-derived monocytes from diabetic mice compared with control mice.
In vitro, advanced glycation end productions (AGEs) induced, expression of HMGB-1 in EPCs and in cell culture supernatants in a dose-dependent manner.
However, inhibition of oxidative stress with N-acetylcysteine (NAC) partially inhibited the induction of HMGB-1 induced by AGEs.
Furthermore, p66shc expression in EPCs induced by AGEs was abrogated by incubation with glycyrrhizin (Gly), while increased superoxide dismutase (SOD) activity in cell culture supernatants was observed in the Gly treated group.
Thus, HMGB-1 may play an important role in diabetes-induced oxidative stress in EPCs via a positive feedback loop involving the AGE/reactive oxygen species/HMGB-1 pathway.
American Psychological Association (APA)
Wu, Han& Li, Ran& Wei, Zhong-Hai& Zhang, Xin-Lin& Chen, Jian-Zhou& Dai, Qing…[et al.]. 2016. Diabetes-Induced Oxidative Stress in Endothelial Progenitor Cells May Be Sustained by a Positive Feedback Loop Involving High Mobility Group Box-1. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113661
Modern Language Association (MLA)
Wu, Han…[et al.]. Diabetes-Induced Oxidative Stress in Endothelial Progenitor Cells May Be Sustained by a Positive Feedback Loop Involving High Mobility Group Box-1. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1113661
American Medical Association (AMA)
Wu, Han& Li, Ran& Wei, Zhong-Hai& Zhang, Xin-Lin& Chen, Jian-Zhou& Dai, Qing…[et al.]. Diabetes-Induced Oxidative Stress in Endothelial Progenitor Cells May Be Sustained by a Positive Feedback Loop Involving High Mobility Group Box-1. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1113661
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113661