The Nrf2HO-1 Axis in Cancer Cell Growth and Chemoresistance
Joint Authors
Pronzato, Maria Adelaide
Piras, S.
Moretta, L.
Furfaro, Anna Lisa
Nitti, Mariapaola
Marinari, Umberto Maria
Traverso, Nicola
Domenicotti, Cinzia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-30
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The transcription factor, nuclear factor erythroid 2 p45-related factor 2 (Nrf2), acts as a sensor of oxidative or electrophilic stresses and plays a pivotal role in redox homeostasis.
Oxidative or electrophilic agents cause a conformational change in the Nrf2 inhibitory protein Keap1 inducing the nuclear translocation of the transcription factor which, through its binding to the antioxidant/electrophilic response element (ARE/EpRE), regulates the expression of antioxidant and detoxifying genes such as heme oxygenase 1 (HO-1).
Nrf2 and HO-1 are frequently upregulated in different types of tumours and correlate with tumour progression, aggressiveness, resistance to therapy, and poor prognosis.
This review focuses on the Nrf2/HO-1 stress response mechanism as a promising target for anticancer treatment which is able to overcome resistance to therapies.
American Psychological Association (APA)
Furfaro, Anna Lisa& Traverso, Nicola& Domenicotti, Cinzia& Piras, S.& Moretta, L.& Marinari, Umberto Maria…[et al.]. 2015. The Nrf2HO-1 Axis in Cancer Cell Growth and Chemoresistance. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113666
Modern Language Association (MLA)
Furfaro, Anna Lisa…[et al.]. The Nrf2HO-1 Axis in Cancer Cell Growth and Chemoresistance. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1113666
American Medical Association (AMA)
Furfaro, Anna Lisa& Traverso, Nicola& Domenicotti, Cinzia& Piras, S.& Moretta, L.& Marinari, Umberto Maria…[et al.]. The Nrf2HO-1 Axis in Cancer Cell Growth and Chemoresistance. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113666
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113666