![](/images/graphics-bg.png)
Oxidative Stress after Surgery on the Immature Heart
Joint Authors
Fudulu, Daniel
Angelini, Gianni D.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Paediatric heart surgery is associated with increased inflammation and the production of reactive oxygen species.
Use of the extracorporeal cardiopulmonary bypass during correction of congenital heart defects generates reactive oxygen species by various mechanisms: haemolysis, neutrophil activation, ischaemia reperfusion injury, reoxygenation injury, or depletion of the endogenous antioxidants.
The immature myocardium is more vulnerable to reactive oxygen species because of developmental differences compared to the adult heart but also because of associated congenital heart diseases that can deplete its antioxidant reserve.
Oxidative stress can be manipulated by various interventions: exogenous antioxidants, use of steroids, cardioplegia, blood prime strategies, or miniaturisation of the cardiopulmonary bypass circuit.
However, it is unclear if modulation of the redox pathways can alter clinical outcomes.
Further studies powered to look at clinical outcomes are needed to define the role of oxidative stress in paediatric patients.
American Psychological Association (APA)
Fudulu, Daniel& Angelini, Gianni D.. 2016. Oxidative Stress after Surgery on the Immature Heart. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113667
Modern Language Association (MLA)
Fudulu, Daniel& Angelini, Gianni D.. Oxidative Stress after Surgery on the Immature Heart. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113667
American Medical Association (AMA)
Fudulu, Daniel& Angelini, Gianni D.. Oxidative Stress after Surgery on the Immature Heart. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113667
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113667